Functional Annotation of Human Long Non-Coding RNAs via Molecular Phenotyping
Type
PreprintAuthors
Ramilowski, JordanYip, Chi Wai
Agrawal, Saumya
Chang, Jen-Chien
Ciani, Yari
Kulakovskiy, Ivan V
Mendez, Mickael
Ooi, Jasmine Li Ching
Ouyang, John F
Parkinson, Nick
Petri, Andreas
Roos, Leonie
Severin, Jessica
Yasuzawa, Kayoko
Abugessaisa, Imad
Akalin, Altuna
Antonov, Ivan
Arner, Erik
Bonetti, Alessandro
Bono, Hidemasa

Borsari, Beatrice
Brombacher, Frank
Cannistraci, Carlo Vittorio
Cardenas, Ryan
Cardon, Melissa
Chang, Howard
Dostie, Josée
Ducoli, Luca
Favorov, Alexander
Fort, Alexandre
Garrido, Diego
Gil, Noa
Gimenez, Juliette
Guler, Reto
Handoko, Lusy
Harshbarger, Jayson
Hasegawa, Akira
Hasegawa, Yuki
Hashimoto, Kosuke

Hayatsu, Norihito
Heutink, Peter
Hirose, Tetsuro
Imada, Eddie L
Itoh, Masayoshi
Kaczkowski, Bogumil
Kanhere, Aditi
Kawabata, Emily
Kawaji, Hideya
Kawashima, Tsugumi
Kelly, Tom
Kojima, Miki
Kondo, Naoto
Koseki, Haruhiko
Kouno, Tsukasa
Kratz, Anton
Kurowska-Stolarska, Mariola
Kwon, Andrew Tae Jun
Leek, Jeffrey
Lennartsson, Andreas
Lizio, Marina
Lopez, Fernando
Luginbühl, Joachim
Maeda, Shiori
Makeev, Vsevolod
Marchionni, Luigi
Medvedeva, Yulia A
Minoda, Aki
Müller, Ferenc
Aguirre, Manuel Munoz
Murata, Mitsuyoshi
Nishiyori, Hiromi
Nitta, Kazuhiro
Noguchi, Shuhei
Noro, Yukihiko
Nurtdinov, Ramil
Okazaki, Yasushi
Orlando, Valerio

Paquette, Denis
Parr, Callum
Rackham, Owen JL
Rizzu, Patrizia
Sanchez, Diego Fernando
Sandelin, Albin
Sanjana, Pillay
Semple, Colin AM
Sharma, Harshita
Shibayama, Youtaro
Sivaraman, Divya
Suzuki, Takahiro
Szumowski, Suzannah
Tagami, Michihira
Taylor, Martin S
Terao, Chikashi
Thodberg, Malte
Thongjuea, Supat
Tripathi, Vidisha
Ulitsky, Igor

Verardo, Roberto
Vorontsov, Ilya
Yamamoto, Chinatsu
Young, Robert S
Baillie, J Kenneth

Forrest, Alistair RR
Guigó, Roderic
Hoffman, Michael M
Hon, Chung Chau
Kasukawa, Takeya
Kauppinen, Sakari
Kere, Juha
Lenhard, Boris
Schneider, Claudio
Suzuki, Harukazu
Yagi, Ken
de Hoon, Michiel
Shin, Jay W
Carninci, Piero

FANTOM consortium
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Date
2019-07-16Permanent link to this record
http://hdl.handle.net/10754/660473
Metadata
Show full item recordAbstract
Long non-coding RNAs (lncRNAs) constitute the majority of transcripts in mammalian genomes and yet, their functions remain largely unknown. We systematically suppressed 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). The resulting transcriptomic profiles recapitulated the observed cellular phenotypes, yielding specific roles for over 40% of analyzed lncRNAs in regulating distinct biological pathways, transcriptional machinery, alternative promoter activity and architecture usage. Overall, combining cellular and molecular profiling provided a powerful approach to unravel the distinct functions of lncRNAs, which we highlight with specific functional roles for ZNF213-AS1 and lnc-KHDC3L-2.Citation
Ramilowski, J., Yip, C. W., Agrawal, S., Chang, J.-C., Ciani, Y., Kulakovskiy, I. V., … Parkinson, N. (2019). Functional Annotation of Human Long Non-Coding RNAs via Molecular Phenotyping. doi:10.1101/700864Publisher
Cold Spring Harbor LaboratoryDOI
10.1101/700864Additional Links
http://biorxiv.org/lookup/doi/10.1101/700864https://www.biorxiv.org/content/biorxiv/early/2019/07/18/700864.full.pdf
ae974a485f413a2113503eed53cd6c53
10.1101/700864