Show simple item record

dc.contributor.authorMartinez Banderas, Aldo
dc.contributor.authorAires, Antonio
dc.contributor.authorQuintanilla, Marta
dc.contributor.authorHolguin Lerma, Jorge Alberto
dc.contributor.authorLozano-Pedraza, Claudia
dc.contributor.authorTeran, Francisco J
dc.contributor.authorMoreno Garcia, Julian
dc.contributor.authorPerez, Jose E.
dc.contributor.authorOoi, Boon S.
dc.contributor.authorRavasi, Timothy
dc.contributor.authorMerzaban, Jasmeen
dc.contributor.authorCortajarena, Aitziber L
dc.contributor.authorKosel, Jürgen
dc.date.accessioned2019-12-05T06:59:10Z
dc.date.available2019-12-05T06:59:10Z
dc.date.issued2019-11-04
dc.identifier.citationMartínez-Banderas, A. I., Aires, A., Quintanilla, M., Holguín-Lerma, J. A., Lozano-Pedraza, C., Teran, F. J., … Kosel, J. (2019). Iron-Based Core–Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy. ACS Applied Materials & Interfaces, 11(47), 43976–43988. doi:10.1021/acsami.9b17512
dc.identifier.doi10.1021/acsami.9b17512
dc.identifier.urihttp://hdl.handle.net/10754/660426
dc.description.abstractCombining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.
dc.description.sponsorshipWe thank Irantzu llarena at CIC biomaGUNE for support with confocal microscopy measurements and Sergei Lopatin from the Imaging and Characterization Corel Lab at KAUST.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/acsami.9b17512
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS applied materials & interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.9b17512.
dc.titleIron-Based Core-Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy.
dc.typeArticle
dc.contributor.departmentBioscience Program
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentDivision of Computer, Electrical, and Mathematical Sciences and Engineering , King Abdullah University of Science and Technology , Thuwal Jeddah 23955-6900 , Saudi Arabia.
dc.contributor.departmentChemical and Biological Engineering Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalACS applied materials & interfaces
dc.rights.embargodate2020-11-05
dc.eprint.versionPost-print
dc.contributor.institutionCIC biomaGUNE , Parque Tecnológico de San Sebastián , Paseo Miramón 182 , 20014 Donostia-San Sebastián , Spain.
dc.contributor.institutioniMdea Nanociencia, Campus Universitario de Cantoblanco , C\Faraday, 9 , 28049 Madrid , Spain.
kaust.personMartinez Banderas, Aldo Isaac
kaust.personHolguin Lerma, Jorge Alberto
kaust.personMoreno, Julián A
kaust.personPerez, Jose E.
kaust.personOoi, Boon S.
kaust.personRavasi, Timothy
kaust.personMerzaban, Jasmeen S.
kaust.personKosel, Jürgen
refterms.dateFOA2020-11-05T00:00:00Z
dc.date.published-online2019-11-04
dc.date.published-print2019-11-27


Files in this item

Thumbnail
Name:
Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery, Photothermal and Magnetic Therapy-ACS-AMI-Just accepted.pdf
Size:
1.121Mb
Format:
PDF
Description:
Accepted manuscript

This item appears in the following Collection(s)

Show simple item record