Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy.
dc.contributor.author | Martinez Banderas, Aldo | |
dc.contributor.author | Aires, Antonio | |
dc.contributor.author | Quintanilla, Marta | |
dc.contributor.author | Holguin Lerma, Jorge Alberto | |
dc.contributor.author | Lozano-Pedraza, Claudia | |
dc.contributor.author | Teran, Francisco J | |
dc.contributor.author | Moreno Garcia, Julian | |
dc.contributor.author | Perez, Jose E. | |
dc.contributor.author | Ooi, Boon S. | |
dc.contributor.author | Ravasi, Timothy | |
dc.contributor.author | Merzaban, Jasmeen | |
dc.contributor.author | Cortajarena, Aitziber L | |
dc.contributor.author | Kosel, Jürgen | |
dc.date.accessioned | 2019-12-05T06:59:10Z | |
dc.date.available | 2019-12-05T06:59:10Z | |
dc.date.issued | 2019-11-04 | |
dc.identifier.citation | Martínez-Banderas, A. I., Aires, A., Quintanilla, M., Holguín-Lerma, J. A., Lozano-Pedraza, C., Teran, F. J., … Kosel, J. (2019). Iron-Based Core–Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy. ACS Applied Materials & Interfaces, 11(47), 43976–43988. doi:10.1021/acsami.9b17512 | |
dc.identifier.doi | 10.1021/acsami.9b17512 | |
dc.identifier.uri | http://hdl.handle.net/10754/660426 | |
dc.description.abstract | Combining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments. | |
dc.description.sponsorship | We thank Irantzu llarena at CIC biomaGUNE for support with confocal microscopy measurements and Sergei Lopatin from the Imaging and Characterization Corel Lab at KAUST. | |
dc.publisher | American Chemical Society (ACS) | |
dc.relation.url | https://pubs.acs.org/doi/10.1021/acsami.9b17512 | |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS applied materials & interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.9b17512. | |
dc.title | Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy. | |
dc.type | Article | |
dc.contributor.department | Bioscience Program | |
dc.contributor.department | Electrical Engineering Program | |
dc.contributor.department | Division of Computer, Electrical, and Mathematical Sciences and Engineering , King Abdullah University of Science and Technology , Thuwal Jeddah 23955-6900 , Saudi Arabia. | |
dc.contributor.department | Chemical and Biological Engineering Program | |
dc.contributor.department | Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division | |
dc.contributor.department | Biological and Environmental Sciences and Engineering (BESE) Division | |
dc.identifier.journal | ACS applied materials & interfaces | |
dc.rights.embargodate | 2020-11-05 | |
dc.eprint.version | Post-print | |
dc.contributor.institution | CIC biomaGUNE , Parque Tecnológico de San Sebastián , Paseo Miramón 182 , 20014 Donostia-San Sebastián , Spain. | |
dc.contributor.institution | iMdea Nanociencia, Campus Universitario de Cantoblanco , C\Faraday, 9 , 28049 Madrid , Spain. | |
kaust.person | Martinez Banderas, Aldo Isaac | |
kaust.person | Holguin Lerma, Jorge Alberto | |
kaust.person | Moreno, Julián A | |
kaust.person | Perez, Jose E. | |
kaust.person | Ooi, Boon S. | |
kaust.person | Ravasi, Timothy | |
kaust.person | Merzaban, Jasmeen S. | |
kaust.person | Kosel, Jürgen | |
refterms.dateFOA | 2020-11-05T00:00:00Z | |
dc.date.published-online | 2019-11-04 | |
dc.date.published-print | 2019-11-27 |
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