Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy.
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ArticleAuthors
Martinez Banderas, Aldo
Aires, Antonio

Quintanilla, Marta
Holguin Lerma, Jorge Alberto

Lozano-Pedraza, Claudia
Teran, Francisco J

Moreno Garcia, Julian

Perez, Jose E.

Ooi, Boon S.

Ravasi, Timothy

Merzaban, Jasmeen

Cortajarena, Aitziber L

Kosel, Jürgen

KAUST Department
Bioscience ProgramElectrical Engineering Program
Division of Computer, Electrical, and Mathematical Sciences and Engineering , King Abdullah University of Science and Technology , Thuwal Jeddah 23955-6900 , Saudi Arabia.
Chemical and Biological Engineering Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Biological and Environmental Sciences and Engineering (BESE) Division
Date
2019-11-04Online Publication Date
2019-11-04Print Publication Date
2019-11-27Embargo End Date
2020-11-05Permanent link to this record
http://hdl.handle.net/10754/660426
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Combining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.Citation
Martínez-Banderas, A. I., Aires, A., Quintanilla, M., Holguín-Lerma, J. A., Lozano-Pedraza, C., Teran, F. J., … Kosel, J. (2019). Iron-Based Core–Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy. ACS Applied Materials & Interfaces, 11(47), 43976–43988. doi:10.1021/acsami.9b17512Sponsors
We thank Irantzu llarena at CIC biomaGUNE for support with confocal microscopy measurements and Sergei Lopatin from the Imaging and Characterization Corel Lab at KAUST.Publisher
American Chemical Society (ACS)Additional Links
https://pubs.acs.org/doi/10.1021/acsami.9b17512ae974a485f413a2113503eed53cd6c53
10.1021/acsami.9b17512