Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy.
AuthorsMartinez Banderas, Aldo
Holguin Lerma, Jorge Alberto
Teran, Francisco J
Moreno Garcia, Julian
Perez, Jose E.
Ooi, Boon S.
Cortajarena, Aitziber L
KAUST DepartmentBioscience Program
Electrical Engineering Program
Division of Computer, Electrical, and Mathematical Sciences and Engineering , King Abdullah University of Science and Technology , Thuwal Jeddah 23955-6900 , Saudi Arabia.
Chemical and Biological Engineering Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Biological and Environmental Sciences and Engineering (BESE) Division
Online Publication Date2019-11-04
Print Publication Date2019-11-27
Embargo End Date2020-11-05
Permanent link to this recordhttp://hdl.handle.net/10754/660426
MetadataShow full item record
AbstractCombining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.
CitationMartínez-Banderas, A. I., Aires, A., Quintanilla, M., Holguín-Lerma, J. A., Lozano-Pedraza, C., Teran, F. J., … Kosel, J. (2019). Iron-Based Core–Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy. ACS Applied Materials & Interfaces, 11(47), 43976–43988. doi:10.1021/acsami.9b17512
SponsorsWe thank Irantzu llarena at CIC biomaGUNE for support with confocal microscopy measurements and Sergei Lopatin from the Imaging and Characterization Corel Lab at KAUST.
PublisherAmerican Chemical Society (ACS)