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dc.contributor.authorHaskovec, Jan
dc.contributor.authorJönsson, Henrik
dc.contributor.authorKreusser, Lisa Maria
dc.contributor.authorMarkowich, Peter A.
dc.date.accessioned2019-12-15T12:41:49Z
dc.date.available2019-11-13T14:00:42Z
dc.date.available2019-12-15T12:41:49Z
dc.date.issued2019-12-12
dc.identifier.citationHaskovec, J., Jönsson, H., Kreusser, L. M., & Markowich, P. (2019). Auxin transport model for leaf venation. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 475(2231), 20190015. doi:10.1098/rspa.2019.0015
dc.identifier.doi10.1098/rspa.2019.0015
dc.identifier.urihttp://hdl.handle.net/10754/660007
dc.description.abstractThe plant hormone auxin controls many aspects of the development of plants. One striking dynamical feature is the self-organization of leaf venation patterns which is driven by high levels of auxin within vein cells. The auxin transport is mediated by specialized membrane-localized proteins. Many venation models have been based on polarly localized efflux-mediator proteins of the PIN family. Here, we investigate a modelling framework for auxin transport with a positive feedback between auxin fluxes and transport capacities that are not necessarily polar, i.e. directional across a cell wall. Our approach is derived from a discrete graph-based model for biological transportation networks, where cells are represented by graph nodes and intercellular membranes by edges. The edges are not a priori oriented and the direction of auxin flow is determined by its concentration gradient along the edge. We prove global existence of solutions to the model and the validity of Murray's Law for its steady states. Moreover, we demonstrate with numerical simulations that the model is able connect an auxin source-sink pair with a mid-vein and that it can also produce branching vein patterns. A significant innovative aspect of our approach is that it allows the passage to a formal macroscopic limit which can be extended to include network growth. We perform mathematical analysis of the macroscopic formulation, showing the global existence of weak solutions for an appropriate parameter range.
dc.description.sponsorshipLMK was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) grant EP/L016516/1 and the German National Academic Foundation (Studienstiftung des Deutschen Volkes)LMK was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) grant EP/L016516/1 and the German National Academic Foundation (Studienstiftung des Deutschen Volkes).
dc.publisherThe Royal Society
dc.relation.urlhttps://royalsocietypublishing.org/doi/10.1098/rspa.2019.0015
dc.rightsArchived with thanks to Proceedings. Mathematical, physical, and engineering sciences
dc.titleAuxin transport model for leaf venation.
dc.typeArticle
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.identifier.journalProceedings. Mathematical, physical, and engineering sciences
dc.eprint.versionPre-print
dc.contributor.institutionSainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK.
dc.contributor.institutionDAMTP, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK.
dc.identifier.arxividarXiv:1901.03244
kaust.personHaskovec, Jan
kaust.personMarkowich, Peter A.
refterms.dateFOA2019-11-13T14:01:50Z


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