STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse

Abstract
Multi-omics approaches use a diversity of high-throughput technologies to profile the different molecular layers of living cells. Ideally, the integration of this information should result in comprehensive systems models of cellular physiology and regulation. However, most multi-omics projects still include a limited number of molecular assays and there have been very few multi-omic studies that evaluate dynamic processes such as cellular growth, development and adaptation. Hence, we lack formal analysis methods and comprehensive multi-omics datasets that can be leveraged to develop true multi-layered models for dynamic cellular systems. Here we present the STATegra multi-omics dataset that combines measurements from up to 10 different omics technologies applied to the same biological system, namely the well-studied mouse pre-B-cell differentiation. STATegra includes high-throughput measurements of chromatin structure, gene expression, proteomics and metabolomics, and it is complemented with single-cell data. To our knowledge, the STATegra collection is the most diverse multi-omics dataset describing a dynamic biological system.

Citation
Gomez-Cabrero, D., Tarazona, S., Ferreirós-Vidal, I., Ramirez, R. N., Company, C., Schmidt, A., … Conesa, A. (2019). STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse. Scientific Data, 6(1). doi:10.1038/s41597-019-0202-7

Acknowledgements
This work has been funded by the European Union Seventh Framework Programme [FP7/2007–2013] under the grant agreement 306000-STATegra. We thank all members of the STATegra consortium for their contributions to this work.

Publisher
Springer Nature

Journal
Scientific Data

DOI
10.1038/s41597-019-0202-7

Additional Links
http://www.nature.com/articles/s41597-019-0202-7

Relations
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  • [Dataset]
    Gomez-Cabrero, D., Tarazona, S., Ferreirós-Vidal, I., Ramirez, R. N., Company, C., Schmidt, A., Reijmers, T., Paul, V. V. S., Marabita, F., Rodríguez-Ubreva, J., Garcia-Gomez, A., Carroll, T., Cooper, L., Ziwei Liang, Gopuraja Dharmalingam, Kloet, F. V. D., Harms, A. C., Balzano-Nogueira, L., Vicenzo Lagani, … Conesa, A. (2020). Metadata record for: STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse [Data set]. figshare. https://doi.org/10.6084/M9.FIGSHARE.9773624.V2. DOI: 10.6084/m9.figshare.9773624.v2 Handle: 10754/664822

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