A Multi-Domain Connectome Convolutional Neural Network for Identifying Schizophrenia from EEG Connectivity Patterns
Type
ArticleKAUST Department
Statistics Program, King Abdullah University of Science and Technology, Thuwal 23955, Saudi ArabiaStatistics Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Date
2019-09-13Online Publication Date
2019-09-13Print Publication Date
2019Permanent link to this record
http://hdl.handle.net/10754/656770
Metadata
Show full item recordAbstract
Objective: We exploit altered patterns in brain functional connectivity as features for automatic discriminative analysis of neuropsychiatric patients. Deep learning methods have been introduced to functional network classification only very recently for fMRI, and the proposed architectures essentially focused on a single type of connectivity measure. Methods: We propose a deep convolutional neural network (CNN) framework for classification of electroencephalogram (EEG)-derived brain connectome in schizophrenia (SZ). To capture complementary aspects of disrupted connectivity in SZ, we explore combination of various connectivity features consisting of time and frequency-domain metrics of effective connectivity based on vector autoregressive model and partial directed coherence, and complex network measures of network topology. We design a novel multi-domain connectome CNN (MDC-CNN) based on a parallel ensemble of 1D and 2D CNNs to integrate the features from various domains and dimensions using different fusion strategies. We also consider an extension to dynamic brain connectivity using the recurrent neural networks. Results: Hierarchical latent representations learned by the multiple convolutional layers from EEG connectivity reveal apparent group differences between SZ and healthy controls (HC). Results on a large resting-state EEG dataset show that the proposed CNNs significantly outperform traditional support vector machine classifiers. The MDC-CNN with combined connectivity features further improves performance over single-domain CNNs using individual features, achieving remarkable accuracy of 91.69% with a decision-level fusion. Conclusion: The proposed MDC-CNN by integrating information from diverse brain connectivity descriptors is able to accurately discriminate SZ from HC. Significance: The new framework is potentially useful for developing diagnostic tools for SZ and other disorders.Citation
Phang, C.-R., Noman, F., Hussain, H., Ting, C.-M., & Ombao, H. (2020). A Multi-Domain Connectome Convolutional Neural Network for Identifying Schizophrenia From EEG Connectivity Patterns. IEEE Journal of Biomedical and Health Informatics, 24(5), 1333–1343. doi:10.1109/jbhi.2019.2941222Additional Links
https://ieeexplore.ieee.org/document/8836535/ae974a485f413a2113503eed53cd6c53
10.1109/jbhi.2019.2941222