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dc.contributor.authorObradovic, Milan
dc.contributor.authorEssack, Magbubah
dc.contributor.authorZafirovic, Sonja
dc.contributor.authorSudar-Milovanovic, Emina
dc.contributor.authorBajic, Vladan P
dc.contributor.authorVan Neste, Christophe Marc
dc.contributor.authorTrpkovic, Andreja
dc.contributor.authorStanimirovic, Julijana
dc.contributor.authorBajic, Vladimir B.
dc.contributor.authorIsenovic, Esma R
dc.date.accessioned2019-09-10T07:22:12Z
dc.date.available2019-09-10T07:22:12Z
dc.date.issued2019-09-05
dc.identifier.doi10.1002/biof.1559
dc.identifier.urihttp://hdl.handle.net/10754/656706
dc.description.abstractRedox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventually lead to cancer and cardiovascular and neurodegenerative diseases. In this review, we focus on redox effects in the vascular system. We pay close attention to the subcompartments of the vascular system (endothelium, smooth muscle cell layer) and give an overview of how redox changes influence those different compartments. We also review the core aspects of redox biology, cardiovascular physiology, and pathophysiology. Moreover, the topic-specific knowledgebase DES-RedoxVasc was used to develop two case studies, one focused on endothelial cells and the other on the vascular smooth muscle cells, as a starting point to possibly extend our knowledge of redox control in vascular biology.
dc.description.sponsorshipThis work is part of the collaboration between the Labora-tory of Radiobiology and Molecular Genetics, Vinca Insti-tute of Nuclear Sciences, University of Belgrade, Belgrade,Serbia and King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Cen-ter (CBRC), Thuwal, Saudi Arabia. This work has beensupported by grants No. 173033 (E.R.I.) from the Ministryof Education, Science and Technological Development,Republic of Serbia and by the KAUST grant OSR#4129(to E.R.I. and V.B.B.), which also supported M.O., S.Z.,E.S.M., and V.P.B. V.B.B. has been supported by the KingAbdullah University of Science and Technology BaseResearch Fund (BAS/1/1606-01-01), and V.B.B. andM.E. by KAUST Office of Sponsored Research (OSR)Awards No. FCC/1/1976-24-01 and FCC/1/1976-17-01.M.O., S.Z., E.S.M, A.T., J.S., and V.P.B. have beensupported by the grants No. 173033 (E.R.I.) and No. 173034from the Ministry of Education, Science and TechnologicalDevelopment, Republic of Serbia
dc.publisherWiley
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/biof.1559
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcardiovascular diseases
dc.subjectcardiovascular system
dc.subjectreactive oxygen species
dc.subjectredox
dc.titleRedox control of vascular biology.
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.identifier.journalBioFactors (Oxford, England)
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionLaboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
kaust.personEssack, Magbubah
kaust.personVan Neste, Christophe Marc
kaust.personBajic, Vladimir B.
kaust.grant.numberBAS/1/1606-01-01
kaust.grant.numberFCC/1/1976-17-01
kaust.grant.numberFCC/1/1976-24-01
refterms.dateFOA2019-09-10T07:22:59Z
kaust.acknowledged.supportUnitCBRC
kaust.acknowledged.supportUnitKAUST Office of Sponsored Research (OSR)


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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.