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dc.contributor.authorJiang, Yunhe
dc.contributor.authorHan, Baoda
dc.contributor.authorZhang, Huoming
dc.contributor.authorMariappan, Kiruthiga
dc.contributor.authorBigeard, Jean
dc.contributor.authorColcombet, Jean
dc.contributor.authorHirt, Heribert
dc.date.accessioned2019-09-08T11:12:48Z
dc.date.available2019-09-08T11:12:48Z
dc.date.issued2019-09-03
dc.identifier.doi10.15252/embr.201947965
dc.identifier.urihttp://hdl.handle.net/10754/656694
dc.description.abstractTo perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.
dc.description.sponsorshipThis work was supported by the King Abdullah University of Science and Technology projects BAS/1/1062-01-01 and URF/1/2965-01-01 and the LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS.
dc.publisherEMBO
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/abs/10.15252/embr.201947965
dc.rightsArchived with thanks to EMBO reports
dc.subjectBIK1
dc.subjectFlg22-triggered immunity
dc.subjectMAP4K4
dc.subjectPP2C38
dc.titleMAP4K4 associates with BIK1 to regulate plant innate immunity.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentProteomics and Protein Expression
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.contributor.departmentPlant Science
dc.contributor.departmentDesert Agriculture Initiative
dc.identifier.journalEMBO reports
dc.rights.embargodate2020-03-03
dc.eprint.versionPost-print
dc.contributor.institutionInstitute of Plant Sciences Paris-Saclay IPS2, CNRS, INRA, Université Paris-Sud, Université Evry, Université Paris-Saclay, Orsay, France.
dc.contributor.institutionInstitute of Plant Sciences Paris-Saclay IPS2, Paris Diderot, Sorbonne Paris-Cité, Orsay, France
dc.contributor.institutionMax F. Perutz Laboratories, University of Vienna, Vienna, Austria
kaust.personJiang, Yunhe
kaust.personHan, Baoda
kaust.personZhang, Huoming
kaust.personMariappan, Kiruthiga
kaust.personHirt, Heribert
kaust.grant.numberBAS/1/1062-01-01
kaust.grant.numberURF/1/2965-01-01


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