KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Proteomics and Protein Expression
Red Sea Research Center (RSRC)
Desert Agriculture Initiative
Embargo End Date2020-03-03
Permanent link to this recordhttp://hdl.handle.net/10754/656694
MetadataShow full item record
AbstractTo perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.
SponsorsThis work was supported by the King Abdullah University of Science and Technology projects BAS/1/1062-01-01 and URF/1/2965-01-01 and the LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS.