MAP4K4 associates with BIK1 to regulate plant innate immunity.

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Type
Article
Authors
Jiang, Yunhe cc
Han, Baoda
Zhang, Huoming cc
Mariappan, Kiruthiga cc
Bigeard, Jean
Colcombet, Jean
Hirt, Heribert cc
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) Division
Proteomics and Protein Expression
Red Sea Research Center (RSRC)
Plant Science
Desert Agriculture Initiative
KAUST Grant Number
BAS/1/1062-01-01
URF/1/2965-01-01
Date
2019-09-03
Embargo End Date
2020-03-03
Permanent link to this record
http://hdl.handle.net/10754/656694

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Abstract
To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.
Sponsors
This work was supported by the King Abdullah University of Science and Technology projects BAS/1/1062-01-01 and URF/1/2965-01-01 and the LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS.
Publisher
EMBO
Journal
EMBO reports
DOI
10.15252/embr.201947965
Additional Links
https://onlinelibrary.wiley.com/doi/abs/10.15252/embr.201947965
Collections
Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Red Sea Research Center (RSRC); Desert Agriculture Initiative