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Type
ArticleAuthors
Jiang, Yunhe
Han, Baoda
Zhang, Huoming

Mariappan, Kiruthiga

Bigeard, Jean
Colcombet, Jean
Hirt, Heribert

KAUST Department
Biological and Environmental Science and Engineering (BESE) DivisionCenter for Desert Agriculture
Hirt Lab
Plant Science
Proteomics, protein expression & cytomet
Red Sea Research Center (RSRC)
KAUST Grant Number
BAS/1/1062-01-01URF/1/2965-01-01
Date
2019-09-02Embargo End Date
2020-03-03Permanent link to this record
http://hdl.handle.net/10754/656694
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Show full item recordAbstract
To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.Citation
Jiang, Y., Han, B., Zhang, H., Mariappan, K. G., Bigeard, J., Colcombet, J., & Hirt, H. (2019). MAP 4K4 associates with BIK 1 to regulate plant innate immunity. EMBO Reports, 20(11). doi:10.15252/embr.201947965Sponsors
This work was supported by the King Abdullah University of Science and Technology projects BAS/1/1062-01-01 and URF/1/2965-01-01 and the LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS.Publisher
EMBOJournal
EMBO reportsAdditional Links
https://onlinelibrary.wiley.com/doi/abs/10.15252/embr.201947965Relations
Is Supplemented By:- [Bioproject]
Title: MAP4K4 regulates flg22-induced immunity responsesPublication Date: 2019-06-11. bioproject: PRJNA548363 Handle: 10754/666544
ae974a485f413a2113503eed53cd6c53
10.15252/embr.201947965