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    MAP4K4 associates with BIK1 to regulate plant innate immunity.

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    94767_2_merged_1565680521.pdf
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    Description:
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    Type
    Article
    Authors
    Jiang, Yunhe cc
    Han, Baoda
    Zhang, Huoming cc
    Mariappan, Kiruthiga cc
    Bigeard, Jean
    Colcombet, Jean
    Hirt, Heribert cc
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Center for Desert Agriculture
    Hirt Lab
    Plant Science
    Proteomics, protein expression & cytomet
    Red Sea Research Center (RSRC)
    KAUST Grant Number
    BAS/1/1062-01-01
    URF/1/2965-01-01
    Date
    2019-09-02
    Embargo End Date
    2020-03-03
    Permanent link to this record
    http://hdl.handle.net/10754/656694
    
    Metadata
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    Abstract
    To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.
    Citation
    Jiang, Y., Han, B., Zhang, H., Mariappan, K. G., Bigeard, J., Colcombet, J., & Hirt, H. (2019). MAP 4K4 associates with BIK 1 to regulate plant innate immunity. EMBO Reports, 20(11). doi:10.15252/embr.201947965
    Sponsors
    This work was supported by the King Abdullah University of Science and Technology projects BAS/1/1062-01-01 and URF/1/2965-01-01 and the LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS.
    Publisher
    EMBO
    Journal
    EMBO reports
    DOI
    10.15252/embr.201947965
    Additional Links
    https://onlinelibrary.wiley.com/doi/abs/10.15252/embr.201947965
    Relations
    Is Supplemented By:
    • [Bioproject]
      Title: MAP4K4 regulates flg22-induced immunity responsesPublication Date: 2019-06-11. bioproject: PRJNA548363 Handle: 10754/666544
    ae974a485f413a2113503eed53cd6c53
    10.15252/embr.201947965
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Red Sea Research Center (RSRC); Center for Desert Agriculture

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