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    State of the climate in 2016

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    Authors
    Aaron-Morrison, Arlene P.
    Ackerman, Steven A.
    Adams, Nicolaus G.
    Adler, Robert F.
    Albanil, Adelina
    Alfaro, E. J.
    Allan, Rob
    Alves, Lincoln M.
    Amador, Jorge A.
    Andreassen, L. M.
    Arendt, A.
    Arévalo, Juan
    Arndt, Derek S.
    Arzhanova, N. M.
    Aschan, M. M.
    Azorin-Molina, César
    Banzon, Viva
    Bardin, M. U.
    Barichivich, Jonathan
    Baringer, Molly O.
    Barreira, Sandra
    Baxter, Stephen
    Bazo, Juan
    Becker, Andreas
    Bedka, Kristopher M.
    Behrenfeld, Michael J.
    Bell, Gerald D.
    Belmont, M.
    Benedetti, Angela
    Bernhard, G.
    Berrisford, Paul
    Berry, David I.
    Bettolli, María L.
    Bhatt, U. S.
    Bidegain, Mario
    Bill, Brian D.
    Billheimer, Sam
    Bissolli, Peter
    Blake, Eric S.
    Blunden, Jessica
    Bosilovich, Michael G.
    Boucher, Olivier
    Boudet, Dagne
    Box, J. E.
    Boyer, Tim
    Braathen, Geir O.
    Bromwich, David H.
    Brown, R.
    Bulygina, Olga N.
    Burgess, D.
    Calderón, Blanca
    Camargo, Suzana J.
    Campbell, Jayaka D.
    Cappelen, J.
    Carrasco, Gualberto
    Carter, Brendan R.
    Chambers, Don P.
    Chandler, Elise
    Christiansen, Hanne H.
    Christy, John R.
    Chung, Daniel
    Chung, E. S.
    Cinque, Kathy
    Clem, Kyle R.
    Coelho, Caio A.
    Cogley, J. G.
    Coldewey-Egbers, Melanie
    Colwell, Steve
    Cooper, Owen R.
    Copland, L.
    Cosca, Catherine E.
    Cross, Jessica N.
    Crotwell, Molly J.
    Crouch, Jake
    Davis, Sean M.
    De Eyto, Elvira
    De Jeu, Richard A.M.
    De Laat, Jos
    Degasperi, Curtis L.
    Degenstein, Doug
    Demircan, M.
    Derksen, C.
    Destin, Dale
    Di Girolamo, Larry
    Di Giuseppe, F.
    Diamond, Howard J.
    Dlugokencky, Ed J.
    Dohan, Kathleen
    Dokulil, Martin T.
    Dolgov, A. V.
    Dolman, A. Johannes
    Domingues, Catia M.
    Donat, Markus G.
    Dong, Shenfu
    Dorigo, Wouter A.
    Dortch, Quay
    Doucette, Greg
    Drozdov, D. S.
    Ducklow, Hugh
    Dunn, Robert J.H.
    Durán-Quesada, Ana M.
    Dutton, Geoff S.
    Ebrahim, A.
    Elkharrim, M.
    Elkins, James W.
    Espinoza, Jhan C.
    Etienne-Leblanc, Sheryl
    Evans, Thomas E.
    Famiglietti, James S.
    Farrell, S.
    Fateh, S.
    Fausto, Robert S.
    Fedaeff, Nava
    Feely, Richard A.
    Feng, Z.
    Fenimore, Chris
    Fettweis, X.
    Fioletov, Vitali E.
    Flemming, Johannes
    Fogarty, Chris T.
    Fogt, Ryan L.
    Folland, Chris
    Fonseca, C.
    Fossheim, M.
    Foster, Michael J.
    Fountain, Andrew
    Francis, S. D.
    Franz, Bryan A.
    Frey, Richard A.
    Frith, Stacey M.
    Froidevaux, Lucien
    Ganter, Catherine
    Garzoli, Silvia
    Gerland, S.
    Gobron, Nadine
    Goldenberg, Stanley B.
    Gomez, R. Sorbonne
    Goni, Gustavo
    Goto, A.
    Grooß, J. U.
    Gruber, Alexander
    Guard, Charles Chip
    Gugliemin, Mauro
    Gupta, S. K.
    Gutiérrez, J. M.
    Hagos, S.
    Hahn, Sebastian
    Haimberger, Leo
    Hakkarainen, J.
    Hall, Brad D.
    Halpert, Michael S.
    Hamlington, Benjamin D.
    Hanna, E.
    Hansen, K.
    Hanssen-Bauer, I.
    Harris, Ian
    Heidinger, Andrew K.
    Heikkilä, A.
    Heil, A.
    Heim, Richard R.
    Hendricks, S.
    Hernández, Marieta
    Hidalgo, Hugo G.
    Hilburn, Kyle
    Ho, Shu Peng Ben
    Holmes, R. M.
    Hu, Zeng Zhen
    Huang, Boyin
    Huelsing, Hannah K.
    Huffman, George J.
    Hughes, C.
    Hurst, Dale F.
    Ialongo, I.
    Ijampy, J. A.
    Ingvaldsen, R. B.
    Inness, Antje
    Isaksen, K.
    Ishii, Masayoshi
    Jevrejeva, Svetlana
    Jiménez, C.
    Jin, Xiangze
    Johannesen, E.
    John, Viju
    Johnsen, B.
    Johnson, Bryan
    Johnson, Gregory C.
    Jones, Philip D.
    Joseph, Annie C.
    Jumaux, Guillaume
    Kabidi, Khadija
    Kaiser, Johannes W.
    Kato, Seiji
    Kazemi, A.
    Keller, Linda M.
    Kendon, Mike
    Kennedy, John
    Kerr, Kenneth
    Kholodov, A. L.
    Khoshkam, Mahbobeh
    Killick, Rachel
    Kim, Hyungjun
    Kim, S. J.
    Kimberlain, Todd B.
    Klotzbach, Philip J.
    Knaff, John A.
    Kobayashi, Shinya
    Kohler, J.
    Korhonen, Johanna
    Korshunova, Natalia N.
    Kovacs, K. M.
    Kramarova, Natalya
    Kratz, D. P.
    Kruger, Andries
    Kruk, Michael C.
    Kudela, Raphael
    Kumar, Arun
    Lakatos, M.
    Lakkala, K.
    Lander, Mark A.
    Landsea, Chris W.
    Lankhorst, Matthias
    Lantz, Kathleen
    Lazzara, Matthew A.
    Lemons, P.
    Leuliette, Eric
    L’Heureux, Michelle
    Lieser, Jan L.
    Lin, I. I.
    Liu, Hongxing
    Liu, Yinghui
    Locarnini, Ricardo
    Loeb, Norman G.
    Lo Monaco, Claire
    Long, Craig S.
    López Álvarez, Luis Alfonso
    Lorrey, Andrew M.
    Loyola, Diego
    Lumpkin, Rick
    Luo, Jing Jia
    Luojus, K.
    Lydersen, C.
    Lyman, John M.
    Maberly, Stephen C.
    Maddux, Brent C.
    Malheiros Ramos, Andrea
    Malkova, G. V.
    Manney, G.
    Marcellin, Vernie
    Marchenko, S. S.
    Marengo, José A.
    Marra, John J.
    Marszelewski, Wlodzimierz
    Martens, B.
    Martínez-Güingla, Rodney
    Massom, Robert A.
    Mata, Mauricio M.
    Mathis, Jeremy T.
    May, Linda
    Mayer, Michael
    Mazloff, Matthew
    McBride, Charlotte
    McCabe, Matthew cc
    McCarthy, M.
    McClelland, J. W.
    McGree, Simon
    McVicar, Tim R.
    Mears, Carl A.
    Meier, W.
    Meinen, Christopher S.
    Mekonnen, A.
    Menéndez, Melisa
    Mengistu Tsidu, G.
    Menzel, W. Paul
    Merchant, Christopher J.
    Meredith, Michael P.
    Merrifield, Mark A.
    Metzl, N.
    Minnis, Patrick
    Miralles, Diego G.
    Mistelbauer, T.
    Mitchum, Gary T.
    Monselesan, Didier
    Monteiro, Pedro
    Montzka, Stephen A.
    Morice, Colin
    Mote, T.
    Mudryk, L.
    Mühle, Jens
    Mullan, A. Brett
    Nash, Eric R.
    Naveira-Garabato, Alberto C.
    Nerem, R. Steven
    Newman, Paul A.
    Nieto, Juan José
    Noetzli, Jeannette
    O’Neel, S.
    Osborn, Tim J.
    Overland, J.
    Oyunjargal, Lamjav
    Parinussa, Robert M.
    Park, E. Hyung
    Parker, David
    Parrington, M.
    Parsons, A. Rost
    Pasch, Richard J.
    Pascual-Ramírez, Reynaldo
    Paterson, Andrew M.
    Paulik, Christoph
    Pearce, Petra R.
    Pelto, Mauri S.
    Peng, Liang
    Perkins-Kirkpatrick, Sarah E.
    Perovich, D.
    Petropavlovskikh, Irina
    Pezza, Alexandre B.
    Phillips, David
    Pinty, Bernard
    Pitts, Michael C.
    Pons, M. R.
    Porter, Avalon O.
    Primicerio, R.
    Proshutinsky, A.
    Quegan, Sean
    Quintana, Juan
    Rahimzadeh, Fatemeh
    Rajeevan, Madhavan
    Randriamarolaza, L.
    Razuvaev, Vyacheslav N.
    Reagan, James
    Reid, Phillip
    Reimer, Christoph
    Rémy, Samuel
    Renwick, James A.
    Revadekar, Jayashree V.
    Richter-Menge, J.
    Riffler, Michael
    Rimmer, Alon
    Rintoul, Steve
    Robinson, David A.
    Rodell, Matthew
    Rodríguez Solís, José L.
    Romanovsky, Vladimir E.
    Ronchail, Josyane
    Rosenlof, Karen H.
    Roth, Chris
    Rusak, James A.
    Sabine, Christopher L.
    Sallée, Jean Bapiste
    Sánchez-Lugo, Ahira
    Santee, Michelle L.
    Sawaengphokhai, P.
    Sayouri, Amal
    Scambos, Ted A.
    Schemm, Jae
    Schladow, S. Geoffrey
    Schmid, Claudia
    Schmid, Martin, Eawag
    Schmidtko, Sunke
    Schreck, Carl J.
    Selkirk, H. B.
    Send, Uwe
    Sensoy, Serhat
    Setzer, Alberto
    Sharp, M.
    Shaw, Adrian
    Shi, Lei
    Shiklomanov, A. I.
    Shiklomanov, Nikolai I.
    Siegel, David A.
    Signorini, Sergio R.
    Sima, Fatou
    Simmons, Adrian J.
    Smeets, C. J.P.P.
    Smith, Sharon L.
    Spence, Jaqueline M.
    Srivastava, A. K.
    Stackhouse, Paul W.
    Stammerjohn, Sharon
    Steinbrecht, Wolfgang
    Stella, José L.
    Stengel, Martin
    Stennett-Brown, Roxann
    Stephenson, Tannecia S.
    Strahan, Susan
    Streletskiy, D. A.
    Sun-Mack, Sunny
    Swart, Sebastiaan
    Sweet, William
    Talley, Lynne D.
    Tamar, Gerard
    Tank, S. E.
    Taylor, Michael A.
    Tedesco, M.
    Teubner, Katrin
    Thoman, R. L.
    Thompson, Philip
    Thomson, L.
    Timmermans, M. L.
    Timofeev, Maxim A.
    Tirnanes, Joaquin A.
    Tobin, Skie
    Trachte, Katja
    Trainer, Vera L.
    Tretiakov, M.
    Trewin, Blair C.
    Trotman, Adrian R.
    Tschudi, M.
    Van As, D.
    Van De Wal, R. S.W.
    van der A., Ronald J.
    Van Der Schalie, Robin
    Van Der Schrier, Gerard
    Van Der Werf, Guido R.
    Van Meerbeeck, Cedric J.
    Velicogna, I.
    Verburg, Piet
    Vigneswaran, Bala
    Vincent, Lucie A.
    Volkov, Denis
    Vose, Russell S.
    Wagner, Wolfgang
    Wåhlin, Anna
    Wahr, J.
    Walsh, J.
    Wang, Chunzai
    Wang, Junhong
    Wang, Lei
    Wang, M.
    Wang, Sheng Hung
    Wanninkhof, Rik
    Watanabe, Shohei
    Weber, Mark
    Weller, Robert A.
    Weyhenmeyer, Gesa A.
    Whitewood, Robert
    Wijffels, Susan E.
    Wilber, Anne C.
    Wild, Jeanette D.
    Willett, Kate M.
    Williams, Michael J.M.
    Willie, Shem
    Wolken, G.
    Wong, Takmeng
    Wood, E. F.
    Woolway, R. Iestyn
    Wouters, B.
    Xue, Yan
    Yamada, Ryuji
    Yim, So Young
    Yin, Xungang
    Young, Steven H.
    Yu, Lisan
    Zahid, H.
    Zambrano, Eduardo
    Zhang, Peiqun
    Zhao, Guanguo
    Zhou, Lin
    Ziemke, Jerry R.
    Love-Brotak, S. Elizabeth
    Gilbert, Kristin
    Maycock, Tom
    Osborne, Susan
    Sprain, Mara
    Veasey, Sara W.
    Ambrose, Barbara J.
    Griffin, Jessicca
    Misch, Deborah J.
    Riddle, Deborah B.
    Young, Teresa
    Romanovsky, Vladimir E.
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Environmental Science and Engineering Program
    Water Desalination and Reuse Research Center (WDRC)
    Date
    2017-09-06
    Online Publication Date
    2017-09-06
    Print Publication Date
    2017-08
    Embargo End Date
    2018-02-01
    Permanent link to this record
    http://hdl.handle.net/10754/656672
    
    Metadata
    Show full item record
    Abstract
    In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs. The 3.5 ± 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest annual increase observed in the 58-year measurement record. The annual global average carbon dioxide concentration at Earth's surface surpassed 400 ppm (402.9 ± 0.1 ppm) for the first time in the modern atmospheric measurement record and in ice core records dating back as far as 800000 years. One of the strongest El Niño events since at least 1950 dissipated in spring, and a weak La Niña evolved later in the year. Owing at least in part to the combination of El Niño conditions early in the year and a long-term upward trend, Earth's surface observed record warmth for a third consecutive year, albeit by a much slimmer margin than by which that record was set in 2015. Above Earth's surface, the annual lower troposphere temperature was record high according to all datasets analyzed, while the lower stratospheric temperature was record low according to most of the in situ and satellite datasets. Several countries, including Mexico and India, reported record high annual temperatures while many others observed near-record highs. A week-long heat wave at the end of April over the northern and eastern Indian peninsula, with temperatures surpassing 44°C, contributed to a water crisis for 330 million people and to 300 fatalities. In the Arctic the 2016 land surface temperature was 2.0°C above the 1981-2010 average, breaking the previous record of 2007, 2011, and 2015 by 0.8°C, representing a 3.5°C increase since the record began in 1900. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 24 March, the sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, tying with 2015 at 7.2% below the 1981-2010 average. The September 2016 Arctic sea ice minimum extent tied with 2007 for the second lowest value on record, 33% lower than the 1981-2010 average. Arctic sea ice cover remains relatively young and thin, making it vulnerable to continued extensive melt. The mass of the Greenland Ice Sheet, which has the capacity to contribute ∼7 m to sea level rise, reached a record low value. The onset of its surface melt was the second earliest, after 2012, in the 37-year satellite record. Sea surface temperature was record high at the global scale, surpassing the previous record of 2015 by about 0.01°C. The global sea surface temperature trend for the 21st centuryto-date of +0.162°C decade-1 is much higher than the longer term 1950-2016 trend of +0.100°C decade-1. Global annual mean sea level also reached a new record high, marking the sixth consecutive year of increase. Global annual ocean heat content saw a slight drop compared to the record high in 2015. Alpine glacier retreat continued around the globe, and preliminary data indicate that 2016 is the 37th consecutive year of negative annual mass balance. Across the Northern Hemisphere, snow cover for each month from February to June was among its four least extensive in the 47-year satellite record. Continuing a pattern below the surface, record high temperatures at 20-m depth were measured at all permafrost observatories on the North Slope of Alaska and at the Canadian observatory on northernmost Ellesmere Island. In the Antarctic, record low monthly surface pressures were broken at many stations, with the southern annular mode setting record high index values in March and June. Monthly high surface pressure records for August and November were set at several stations. During this period, record low daily and monthly sea ice extents were observed, with the November mean sea ice extent more than 5 standard deviations below the 1981-2010 average. These record low sea ice values contrast sharply with the record high values observed during 2012-14. Over the region, springtime Antarctic stratospheric ozone depletion was less severe relative to the 1991-2006 average, but ozone levels were still low compared to pre-1990 levels. Closer to the equator, 93 named tropical storms were observed during 2016, above the 1981-2010 average of 82, but fewer than the 101 storms recorded in 2015. Three basins-the North Atlantic, and eastern and western North Pacific-experienced above-normal activity in 2016. The Australian basin recorded its least active season since the beginning of the satellite era in 1970. Overall, four tropical cyclones reached the Saffir-Simpson category 5 intensity level. The strong El Niño at the beginning of the year that transitioned to a weak La Niña contributed to enhanced precipitation variability around the world. Wet conditions were observed throughout the year across southern South America, causing repeated heavy flooding in Argentina, Paraguay, and Uruguay. Wetter-than-usual conditions were also observed for eastern Europe and central Asia, alleviating the drought conditions of 2014 and 2015 in southern Russia. In the United States, California had its first wetter-than-average year since 2012, after being plagued by drought for several years. Even so, the area covered by drought in 2016 at the global scale was among the largest in the post-1950 record. For each month, at least 12% of land surfaces experienced severe drought conditions or worse, the longest such stretch in the record. In northeastern Brazil, drought conditions were observed for the fifth consecutive year, making this the longest drought on record in the region. Dry conditions were also observed in western Bolivia and Peru; it was Bolivia's worst drought in the past 25 years. In May, with abnormally warm and dry conditions already prevailing over western Canada for about a year, the human-induced Fort McMurray wildfire burned nearly 590000 hectares and became the costliest disaster in Canadian history, with $3 billion (U.S. dollars) in insured losses.
    Citation
    Blunden, J., & Arndt, D. S. (2017). State of the Climate in 2016. Bulletin of the American Meteorological Society, 98(8), Si–S280. doi:10.1175/2017bamsstateoftheclimate.1
    Sponsors
    The report's editors wish to thank the AMS Journals editorial staff, in particular Melissa Fernau, for facilitating the document, and to the NCEI graphics team for laying the document out and executing the countless number of technical edits needed. We also wish to express our sincere and deep gratitude to Dr. Rick Rosen, who served as the AMS special editor for this report. Dr. Rosen's handling of the reviews was at the same time rigorous and responsive, and greatly improved the document.
    Publisher
    American Meteorological Society
    Journal
    Bulletin of the American Meteorological Society
    DOI
    10.1175/2017BAMSStateoftheClimate.1
    Additional Links
    http://journals.ametsoc.org/doi/10.1175/2017BAMSStateoftheClimate.1
    ae974a485f413a2113503eed53cd6c53
    10.1175/2017BAMSStateoftheClimate.1
    Scopus Count
    Collections
    Biological and Environmental Science and Engineering (BESE) Division; Environmental Science and Engineering Program; Water Desalination and Reuse Research Center (WDRC); Books

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      Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

      Menden, Michael P.; Wang, Dennis; Mason, Mike J.; Szalai, Bence; Bulusu, Krishna C.; Guan, Yuanfang; Yu, Thomas; Kang, Jaewoo; Jeon, Minji; Wolfinger, Russ; Nguyen, Tin; Zaslavskiy, Mikhail; Abante, Jordi; Abecassis, Barbara Schmitz; Aben, Nanne; Aghamirzaie, Delasa; Aittokallio, Tero; Akhtari, Farida S.; Al-lazikani, Bissan; Alam, Tanvir; Allam, Amin; Allen, Chad; de Almeida, Mariana Pelicano; Altarawy, Doaa; Alves, Vinicius; Amadoz, Alicia; Anchang, Benedict; Antolin, Albert A.; Ash, Jeremy R.; Aznar, Victoria Romeo; Ba Alawi, Wail; Bagheri, Moeen; Bajic, Vladimir B.; Ball, Gordon; Ballester, Pedro J.; Baptista, Delora; Bare, Christopher; Bateson, Mathilde; Bender, Andreas; Bertrand, Denis; Wijayawardena, Bhagya; Boroevich, Keith A.; Bosdriesz, Evert; Bougouffa, Salim; Bounova, Gergana; Brouwer, Thomas; Bryant, Barbara; Calaza, Manuel; Calderone, Alberto; Calza, Stefano; Capuzzi, Stephen; Carbonell-Caballero, Jose; Carlin, Daniel; Carter, Hannah; Castagnoli, Luisa; Celebi, Remzi; Cesareni, Gianni; Chang, Hyeokyoon; Chen, Guocai; Chen, Haoran; Chen, Huiyuan; Cheng, Lijun; Chernomoretz, Ariel; Chicco, Davide; Cho, Kwang Hyun; Cho, Sunghwan; Choi, Daeseon; Choi, Jaejoon; Choi, Kwanghun; Choi, Minsoo; Cock, Martine De; Coker, Elizabeth; Cortes-Ciriano, Isidro; Cserzö, Miklós; Cubuk, Cankut; Curtis, Christina; Daele, Dries Van; Dang, Cuong C.; Dijkstra, Tjeerd; Dopazo, Joaquin; Draghici, Sorin; Drosou, Anastasios; Dumontier, Michel; Ehrhart, Friederike; Eid, Fatma Elzahraa; ElHefnawi, Mahmoud; Elmarakeby, Haitham; van Engelen, Bo; Engin, Hatice Billur; de Esch, Iwan; Evelo, Chris; Falcao, Andre O.; Farag, Sherif; Fernandez-Lozano, Carlos; Fisch, Kathleen; Flobak, Asmund; Fornari, Chiara; Foroushani, Amir B.K.; Fotso, Donatien Chedom; Fourches, Denis; Friend, Stephen; Frigessi, Arnoldo; Gao, Feng; Gao, Xiaoting; Gerold, Jeffrey M.; Gestraud, Pierre; Ghosh, Samik; Gillberg, Jussi; Godoy-Lorite, Antonia; Godynyuk, Lizzy; Godzik, Adam; Goldenberg, Anna; Gomez-Cabrero, David; Gonen, Mehmet; de Graaf, Chris; Gray, Harry; Grechkin, Maxim; Guimera, Roger; Guney, Emre; Haibe-Kains, Benjamin; Han, Younghyun; Hase, Takeshi; He, Di; He, Liye; Heath, Lenwood S.; Hellton, Kristoffer H.; Helmer-Citterich, Manuela; Hidalgo, Marta R.; Hidru, Daniel; Hill, Steven M.; Hochreiter, Sepp; Hong, Seungpyo; Hovig, Eivind; Hsueh, Ya Chih; Hu, Zhiyuan; Huang, Justin K.; Huang, R. Stephanie; Hunyady, László; Hwang, Jinseub; Hwang, Tae Hyun; Hwang, Woochang; Hwang, Yongdeuk; Isayev, Olexandr; Don’t Walk, Oliver Bear; Jack, John; Jahandideh, Samad; Ji, Jiadong; Jo, Yousang; Kamola, Piotr J.; Kanev, Georgi K.; Karacosta, Loukia; Karimi, Mostafa; Kaski, Samuel; Kazanov, Marat; Khamis, Abdullah M.; Khan, Suleiman Ali; Kiani, Narsis A.; Kim, Allen; Kim, Jinhan; Kim, Juntae; Kim, Kiseong; Kim, Kyung; Kim, Sunkyu; Kim, Yongsoo; Kim, Yunseong; Kirk, Paul D.W.; Kitano, Hiroaki; Klambauer, Gunter; Knowles, David; Ko, Melissa; Kohn-Luque, Alvaro; Kooistra, Albert J.; Kuenemann, Melaine A.; Kuiper, Martin; Kurz, Christoph; Kwon, Mijin; van Laarhoven, Twan; Laegreid, Astrid; Lederer, Simone; Lee, Heewon; Lee, Jeon; Lee, Yun Woo; Lepp_aho, Eemeli; Lewis, Richard; Li, Jing; Li, Lang; Liley, James; Lim, Weng Khong; Lin, Chieh; Liu, Yiyi; Lopez, Yosvany; Low, Joshua; Lysenko, Artem; Machado, Daniel; Madhukar, Neel; Maeyer, Dries De; Malpartida, Ana Belen; Mamitsuka, Hiroshi; Marabita, Francesco; Marchal, Kathleen; Marttinen, Pekka; Mason, Daniel; Mazaheri, Alireza; Mehmood, Arfa; Mehreen, Ali; Michaut, Magali; Miller, Ryan A.; Mitsopoulos, Costas; Modos, Dezso; Moerbeke, Marijke Van; Moo, Keagan; Motsinger-Reif, Alison; Movva, Rajiv; Muraru, Sebastian; Muratov, Eugene; Mushthofa, Mushthofa; Nagarajan, Niranjan; Nakken, Sigve; Nath, Aritro; Neuvial, Pierre; Newton, Richard; Ning, Zheng; Niz, Carlos De; Oliva, Baldo; Olsen, Catharina; Palmeri, Antonio; Panesar, Bhawan; Papadopoulos, Stavros; Park, Jaesub; Park, Seonyeong; Park, Sungjoon; Pawitan, Yudi; Peluso, Daniele; Pendyala, Sriram; Peng, Jian; Perfetto, Livia; Pirro, Stefano; Plevritis, Sylvia; Politi, Regina; Poon, Hoifung; Porta, Eduard; Prellner, Isak; Preuer, Kristina; Pujana, Miguel Angel; Ramnarine, Ricardo; Reid, John E.; Reyal, Fabien; Richardson, Sylvia; Ricketts, Camir; Rieswijk, Linda; Rocha, Miguel; Rodriguez-Gonzalvez, Carmen; Roell, Kyle; Rotroff, Daniel; de Ruiter, Julian R.; Rukawa, Ploy; Sadacca, Benjamin; Safikhani, Zhaleh; Safitri, Fita; Sales-Pardo, Marta; Sauer, Sebastian; Schlichting, Moritz; Seoane, Jose A.; Serra, Jordi; Shang, Ming Mei; Sharma, Alok; Sharma, Hari; Shen, Yang; Shiga, Motoki; Shin, Moonshik; Shkedy, Ziv; Shopsowitz, Kevin; Sinai, Sam; Skola, Dylan; Smirnov, Petr; Soerensen, Izel Fourie; Soerensen, Peter; Song, Je Hoon; Song, Sang Ok; Soufan, Othman; Spitzmueller, Andreas; Steipe, Boris; Suphavilai, Chayaporn; Tamayo, Sergio Pulido; Tamborero, David; Tang, Jing; Tanoli, Zia ur Rehman; Tarres-Deulofeu, Marc; Tegner, Jesper; Thommesen, Liv; Tonekaboni, Seyed Ali Madani; Tran, Hong; Troyer, Ewoud De; Truong, Amy; Tsunoda, Tatsuhiko; Turu, Gábor; Tzeng, Guang Yo; Verbeke, Lieven; Videla, Santiago; Vis, Daniel; Voronkov, Andrey; Votis, Konstantinos; Wang, Ashley; Wang, Hong Qiang Horace; Wang, Po Wei; wang, sheng; Wang, Wei; Wang, Xiaochen; Wang, Xin; Wennerberg, Krister; Wernisch, Lorenz; Wessels, Lodewyk; van Westen, Gerard J.P.; Westerman, Bart A.; White, Simon Richard; Willighagen, Egon; Wurdinger, Tom; Xie, Lei; Xie, Shuilian; Xu, Hua; Yadav, Bhagwan; Yau, Christopher; Yeerna, Huwate; Yin, Jia Wei; Yu, Michael; Yu, Min Hwan; Yun, So Jeong; Zakharov, Alexey; Zamichos, Alexandros; Zanin, Massimiliano; Zeng, Li; Zenil, Hector; Zhang, Frederick; Zhang, Pengyue; Zhang, Wei; Zhao, Hongyu; Zhao, Lan; Zheng, Wenjin; Zoufir, Azedine; Zucknick, Manuela; Jang, In Sock; Ghazoui, Zara; Aghamirzaie, Delasa; Vogel, Robert; Neto, Elias Chaibub; Norman, Thea; Tang, Eric K.Y.; Garnett, Mathew J.; Veroli, Giovanni Y.Di; Fawell, Stephen; Altarawy, Doaa; Alves, Vinicius; Dry, Jonathan R.; Anchang, Benedict (Nature Communications, Springer Nature, 2019-06-17) [Article]
      The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.
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      GlobalSharkMovement/GlobalSpatialRisk: Repository containing raw data, R scripts and the GSMP Rpackage for the manuscript "Global spatial risk assessment of sharks under the footprint of fisheries"

      Queiroz, Nuno; Humphries, Nicolas E; Couto, Ana; Vedor, Marisa; da Costa, Ivo; Sequeira, Ana M M; Mucientes, Gonzalo; Santos, António M; Abascal, Francisco J; Abercrombie, Debra L; Abrantes, Katya; Acuña-Marrero, David; Afonso, André S; Afonso, Pedro; Anders, Darrell; Araujo, Gonzalo; Arauz, Randall; Bach, Pascal; Barnett, Adam; Bernal, Diego; Berumen, Michael L.; Lion, Sandra Bessudo; Bezerra, Natalia P A; Blaison, Antonin V; Block, Barbara A; Bond, Mark E; Bradford, Russell W; Braun, Camrin D; Brooks, Edward J; Brooks, Annabelle; Brown, Judith; Bruce, Barry D; Byrne, Michael E; Campana, Steven E; Carlisle, Aaron B; Chapman, Demian D; Chapple, Taylor K; Chisholm, John; Clarke, Christopher R; Clua, Eric G; Cochran, Jesse E M; Crochelet, Estelle C; Dagorn, Laurent; Daly, Ryan; Cortés, Daniel Devia; Doyle, Thomas K; Drew, Michael; Duffy, Clinton A J; Erikson, Thor; Espinoza, Eduardo; Ferreira, Luciana C; Ferretti, Francesco; Filmalter, John D; Fischer, G Chris; Fitzpatrick, Richard; Fontes, Jorge; Forget, Fabien; Fowler, Mark; Francis, Malcolm P; Gallagher, Austin J; Gennari, Enrico; Goldsworthy, Simon D; Gollock, Matthew J; Green, Jonathan R; Gustafson, Johan A; Guttridge, Tristan L; Guzman, Hector M; Hammerschlag, Neil; Harman, Luke; Hazin, Fábio H V; Heard, Matthew; Hearn, Alex R; Holdsworth, John C; Holmes, Bonnie J; Howey, Lucy A; Hoyos, Mauricio; Hueter, Robert E; Hussey, Nigel E; Huveneers, Charlie; Irion, Dylan T; Jacoby, David M P; Jewell, Oliver J D; Johnson, Ryan; Jordan, Lance K B; Jorgensen, Salvador J; Joyce, Warren; Daly, Clare A Keating; Ketchum, James T; Klimley, A Peter; Kock, Alison A; Koen, Pieter; Ladino, Felipe; Lana, Fernanda O; Lea, James S E; Llewellyn, Fiona; Lyon, Warrick S; MacDonnell, Anna; Macena, Bruno C L; Marshall, Heather; McAllister, Jaime D; McAuley, Rory; Meÿer, Michael A; Morris, John J; Nelson, Emily R; Papastamatiou, Yannis P; Patterson, Toby A; Peñaherrera-Palma, Cesar; Pepperell, Julian G; Pierce, Simon J; Poisson, Francois; Quintero, Lina Maria; Richardson, Andrew J; Rogers, Paul J; Rohner, Christoph A; Rowat, David R L; Samoilys, Melita; Semmens, Jayson M; Sheaves, Marcus; Shillinger, George; Shivji, Mahmood; Singh, Sarika; Skomal, Gregory B; Smale, Malcolm J; Snyders, Laurenne B; Soler, German; Soria, Marc; Stehfest, Kilian M; Stevens, John D; Thorrold, Simon R; Tolotti, Mariana T; Towner, Alison; Travassos, Paulo; Tyminski, John P; Vandeperre, Frederic; Vaudo, Jeremy J; Watanabe, Yuuki Y; Weber, Sam B; Wetherbee, Bradley M; White, Timothy D; Williams, Sean; Zárate, Patricia M; Harcourt, Robert; Hays, Graeme C; Meekan, Mark G; Thums, Michele; Irigoien, Xabier; Eguiluz, Victor M; Duarte, Carlos M.; Sousa, Lara L; Simpson, Samantha J; Southall, Emily J; Sims, David W (Github, 2019-04-30) [Software]
      Repository containing raw data, R scripts and the GSMP Rpackage for the manuscript "Global spatial risk assessment of sharks under the footprint of fisheries"
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      Reply to: Shark mortality cannot be assessed by fishery overlap alone.

      Queiroz, Nuno; Humphries, Nicolas E; Couto, Ana; Vedor, Marisa; da Costa, Ivo; Sequeira, Ana M M; Mucientes, Gonzalo; Santos, António M; Abascal, Francisco J; Abercrombie, Debra L; Abrantes, Katya; Acuña-Marrero, David; Afonso, André S; Afonso, Pedro; Anders, Darrell; Araujo, Gonzalo; Arauz, Randall; Bach, Pascal; Barnett, Adam; Bernal, Diego; Berumen, Michael L.; Lion, Sandra Bessudo; Bezerra, Natalia P A; Blaison, Antonin V; Block, Barbara A; Bond, Mark E; Bonfil, Ramon; Bradford, Russell W; Braun, Camrin D; Brooks, Edward J; Brooks, Annabelle; Brown, Judith; Bruce, Barry D; Byrne, Michael E; Campana, Steven E; Carlisle, Aaron B; Chapman, Demian D; Chapple, Taylor K; Chisholm, John; Clarke, Christopher R; Clua, Eric G; Cochran, Jesse E M; Crochelet, Estelle C; Dagorn, Laurent; Daly, Ryan; Cortés, Daniel Devia; Doyle, Thomas K; Drew, Michael; Duffy, Clinton A J; Erikson, Thor; Espinoza, Eduardo; Ferreira, Luciana C; Ferretti, Francesco; Filmalter, John D; Fischer, G Chris; Fitzpatrick, Richard; Fontes, Jorge; Forget, Fabien; Fowler, Mark; Francis, Malcolm P; Gallagher, Austin J; Gennari, Enrico; Goldsworthy, Simon D; Gollock, Matthew J; Green, Jonathan R; Gustafson, Johan A; Guttridge, Tristan L; Guzman, Hector M; Hammerschlag, Neil; Harman, Luke; Hazin, Fábio H V; Heard, Matthew; Hearn, Alex R; Holdsworth, John C; Holmes, Bonnie J; Howey, Lucy A; Hoyos, Mauricio; Hueter, Robert E; Hussey, Nigel E; Huveneers, Charlie; Irion, Dylan T; Jacoby, David M P; Jewell, Oliver J D; Johnson, Ryan; Jordan, Lance K B; Joyce, Warren; Keating Daly, Clare A; Ketchum, James T; Klimley, A Peter; Kock, Alison A; Koen, Pieter; Ladino, Felipe; Lana, Fernanda O; Lea, James S E; Llewellyn, Fiona; Lyon, Warrick S; MacDonnell, Anna; Macena, Bruno C L; Marshall, Heather; McAllister, Jaime D; Meÿer, Michael A; Morris, John J; Nelson, Emily R; Papastamatiou, Yannis P; Peñaherrera-Palma, Cesar; Pierce, Simon J; Poisson, Francois; Quintero, Lina Maria; Richardson, Andrew J; Rogers, Paul J; Rohner, Christoph A; Rowat, David R L; Samoilys, Melita; Semmens, Jayson M; Sheaves, Marcus; Shillinger, George; Shivji, Mahmood; Singh, Sarika; Skomal, Gregory B; Smale, Malcolm J; Snyders, Laurenne B; Soler, German; Soria, Marc; Stehfest, Kilian M; Thorrold, Simon R; Tolotti, Mariana T; Towner, Alison; Travassos, Paulo; Tyminski, John P; Vandeperre, Frederic; Vaudo, Jeremy J; Watanabe, Yuuki Y; Weber, Sam B; Wetherbee, Bradley M; White, Timothy D; Williams, Sean; Zárate, Patricia M; Harcourt, Robert; Hays, Graeme C; Meekan, Mark G; Thums, Michele; Irigoien, Xabier; Eguiluz, Victor M; Duarte, Carlos M.; Sousa, Lara L; Simpson, Samantha J; Southall, Emily J; Sims, David W (Springer Science and Business Media LLC, 2021-07-07) [Article]
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