• Login
    View Item 
    •   Home
    • Research
    • Articles
    • View Item
    •   Home
    • Research
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguidePlumX LibguideSubmit an Item

    Statistics

    Display statistics

    An organic electrochemical transistor integrated with a molecularly selective isoporous membrane for amyloid-β detection.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Revised Manuscript_Wustoni et al_Biosensors and Bioelectronic 2019.pdf
    Size:
    834.4Kb
    Format:
    PDF
    Description:
    Accepted Manuscript
    Embargo End Date:
    2021-08-26
    Download
    Thumbnail
    Name:
    1-s2.0-S0956566319306402-mmc1.docx
    Size:
    3.413Mb
    Format:
    Microsoft Word 2007
    Description:
    supplementary file
    Embargo End Date:
    2021-08-26
    Download
    Type
    Article
    Authors
    Wustoni, Shofarul cc
    Wang, Shaofei cc
    Alvarez, Juan R
    Hidalgo, Tania C
    Nunes, Suzana Pereira cc
    Inal, Sahika cc
    KAUST Department
    Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Environmental Science and Engineering Program
    Date
    2019-08-05
    Online Publication Date
    2019-08-05
    Print Publication Date
    2019-10
    Embargo End Date
    2021-08-26
    Permanent link to this record
    http://hdl.handle.net/10754/656660
    
    Metadata
    Show full item record
    Abstract
    Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with severe memory loss and impaired cognitive skills. A common pathological change found in AD-affected brains is the accumulation of a peptide named amyloid-β (Aβ) that can form plaques. Aβ aggregates are visible to structural scanning tools; however, these bulky and expensive instruments are accessible to trained personnel in clinical settings only, thus hampering timely diagnosis of the disease, particularly in low-resource settings. In this work, we design an organic electrochemical transistor (OECT) for in vitro detection of Aβ aggregates in human serum. The OECT channel is integrated with a nanostructured isoporous membrane which has a strong affinity for Aβ aggregates. The detection mechanism relies on the membrane capturing Aβ aggregates larger than the size of its pores and thus blocking the penetration of electrolyte ions into the channel underneath. Combining the high transconductance of the OECT with the precise porosity and selectivity of the membrane, the device detects the presence of Aβ aggregates in human serum samples with excellent sensitivity. This is the first-time demonstration of a biofunctionalized, nanostructured, and isoporous membrane integrated with a high-performance transistor for biosensing. This robust, low-power, non-invasive, and miniaturized sensor aids in the development of point-of-care tools for early diagnosis of AD.
    Citation
    Wustoni, S., Wang, S., Alvarez, J. R., Hidalgo, T. C., Nunes, S. P., & Inal, S. (2019). An organic electrochemical transistor integrated with a molecularly selective isoporous membrane for amyloid-β detection. Biosensors and Bioelectronics, 143, 111561. doi:10.1016/j.bios.2019.111561
    Sponsors
    S. W. and S. I. gratefully acknowledge financial support from the KAUST Office of Sponsored Research (OSR) under Award CRF-2019- SENSORS-2719.
    Publisher
    Elsevier BV
    Journal
    Biosensors & bioelectronics
    DOI
    10.1016/j.bios.2019.111561
    Additional Links
    https://linkinghub.elsevier.com/retrieve/pii/S0956566319306402
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bios.2019.111561
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Environmental Science and Engineering Program

    entitlement

     
    DSpace software copyright © 2002-2021  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.