Show simple item record

dc.contributor.authorMenden, Michael P.
dc.contributor.authorWang, Dennis
dc.contributor.authorMason, Mike J.
dc.contributor.authorSzalai, Bence
dc.contributor.authorBulusu, Krishna C.
dc.contributor.authorGuan, Yuanfang
dc.contributor.authorYu, Thomas
dc.contributor.authorKang, Jaewoo
dc.contributor.authorJeon, Minji
dc.contributor.authorWolfinger, Russ
dc.contributor.authorNguyen, Tin
dc.contributor.authorZaslavskiy, Mikhail
dc.contributor.authorAbante, Jordi
dc.contributor.authorAbecassis, Barbara Schmitz
dc.contributor.authorAben, Nanne
dc.contributor.authorAghamirzaie, Delasa
dc.contributor.authorAittokallio, Tero
dc.contributor.authorAkhtari, Farida S.
dc.contributor.authorAl-lazikani, Bissan
dc.contributor.authorAlam, Tanvir
dc.contributor.authorAllam, Amin
dc.contributor.authorAllen, Chad
dc.contributor.authorde Almeida, Mariana Pelicano
dc.contributor.authorAltarawy, Doaa
dc.contributor.authorAlves, Vinicius
dc.contributor.authorAmadoz, Alicia
dc.contributor.authorAnchang, Benedict
dc.contributor.authorAntolin, Albert A.
dc.contributor.authorAsh, Jeremy R.
dc.contributor.authorAznar, Victoria Romeo
dc.contributor.authorBa Alawi, Wail
dc.contributor.authorBagheri, Moeen
dc.contributor.authorBajic, Vladimir B.
dc.contributor.authorBall, Gordon
dc.contributor.authorBallester, Pedro J.
dc.contributor.authorBaptista, Delora
dc.contributor.authorBare, Christopher
dc.contributor.authorBateson, Mathilde
dc.contributor.authorBender, Andreas
dc.contributor.authorBertrand, Denis
dc.contributor.authorWijayawardena, Bhagya
dc.contributor.authorBoroevich, Keith A.
dc.contributor.authorBosdriesz, Evert
dc.contributor.authorBougouffa, Salim
dc.contributor.authorBounova, Gergana
dc.contributor.authorBrouwer, Thomas
dc.contributor.authorBryant, Barbara
dc.contributor.authorCalaza, Manuel
dc.contributor.authorCalderone, Alberto
dc.contributor.authorCalza, Stefano
dc.contributor.authorCapuzzi, Stephen
dc.contributor.authorCarbonell-Caballero, Jose
dc.contributor.authorCarlin, Daniel
dc.contributor.authorCarter, Hannah
dc.contributor.authorCastagnoli, Luisa
dc.contributor.authorCelebi, Remzi
dc.contributor.authorCesareni, Gianni
dc.contributor.authorChang, Hyeokyoon
dc.contributor.authorChen, Guocai
dc.contributor.authorChen, Haoran
dc.contributor.authorChen, Huiyuan
dc.contributor.authorCheng, Lijun
dc.contributor.authorChernomoretz, Ariel
dc.contributor.authorChicco, Davide
dc.contributor.authorCho, Kwang Hyun
dc.contributor.authorCho, Sunghwan
dc.contributor.authorChoi, Daeseon
dc.contributor.authorChoi, Jaejoon
dc.contributor.authorChoi, Kwanghun
dc.contributor.authorChoi, Minsoo
dc.contributor.authorCock, Martine De
dc.contributor.authorCoker, Elizabeth
dc.contributor.authorCortes-Ciriano, Isidro
dc.contributor.authorCserzö, Miklós
dc.contributor.authorCubuk, Cankut
dc.contributor.authorCurtis, Christina
dc.contributor.authorDaele, Dries Van
dc.contributor.authorDang, Cuong C.
dc.contributor.authorDijkstra, Tjeerd
dc.contributor.authorDopazo, Joaquin
dc.contributor.authorDraghici, Sorin
dc.contributor.authorDrosou, Anastasios
dc.contributor.authorDumontier, Michel
dc.contributor.authorEhrhart, Friederike
dc.contributor.authorEid, Fatma Elzahraa
dc.contributor.authorElHefnawi, Mahmoud
dc.contributor.authorElmarakeby, Haitham
dc.contributor.authorvan Engelen, Bo
dc.contributor.authorEngin, Hatice Billur
dc.contributor.authorde Esch, Iwan
dc.contributor.authorEvelo, Chris
dc.contributor.authorFalcao, Andre O.
dc.contributor.authorFarag, Sherif
dc.contributor.authorFernandez-Lozano, Carlos
dc.contributor.authorFisch, Kathleen
dc.contributor.authorFlobak, Asmund
dc.contributor.authorFornari, Chiara
dc.contributor.authorForoushani, Amir B.K.
dc.contributor.authorFotso, Donatien Chedom
dc.contributor.authorFourches, Denis
dc.contributor.authorFriend, Stephen
dc.contributor.authorFrigessi, Arnoldo
dc.contributor.authorGao, Feng
dc.contributor.authorGao, Xiaoting
dc.contributor.authorGerold, Jeffrey M.
dc.contributor.authorGestraud, Pierre
dc.contributor.authorGhosh, Samik
dc.contributor.authorGillberg, Jussi
dc.contributor.authorGodoy-Lorite, Antonia
dc.contributor.authorGodynyuk, Lizzy
dc.contributor.authorGodzik, Adam
dc.contributor.authorGoldenberg, Anna
dc.contributor.authorGomez-Cabrero, David
dc.contributor.authorGonen, Mehmet
dc.contributor.authorde Graaf, Chris
dc.contributor.authorGray, Harry
dc.contributor.authorGrechkin, Maxim
dc.contributor.authorGuimera, Roger
dc.contributor.authorGuney, Emre
dc.contributor.authorHaibe-Kains, Benjamin
dc.contributor.authorHan, Younghyun
dc.contributor.authorHase, Takeshi
dc.contributor.authorHe, Di
dc.contributor.authorHe, Liye
dc.contributor.authorHeath, Lenwood S.
dc.contributor.authorHellton, Kristoffer H.
dc.contributor.authorHelmer-Citterich, Manuela
dc.contributor.authorHidalgo, Marta R.
dc.contributor.authorHidru, Daniel
dc.contributor.authorHill, Steven M.
dc.contributor.authorHochreiter, Sepp
dc.contributor.authorHong, Seungpyo
dc.contributor.authorHovig, Eivind
dc.contributor.authorHsueh, Ya Chih
dc.contributor.authorHu, Zhiyuan
dc.contributor.authorHuang, Justin K.
dc.contributor.authorHuang, R. Stephanie
dc.contributor.authorHunyady, László
dc.contributor.authorHwang, Jinseub
dc.contributor.authorHwang, Tae Hyun
dc.contributor.authorHwang, Woochang
dc.contributor.authorHwang, Yongdeuk
dc.contributor.authorIsayev, Olexandr
dc.contributor.authorDon’t Walk, Oliver Bear
dc.contributor.authorJack, John
dc.contributor.authorJahandideh, Samad
dc.contributor.authorJi, Jiadong
dc.contributor.authorJo, Yousang
dc.contributor.authorKamola, Piotr J.
dc.contributor.authorKanev, Georgi K.
dc.contributor.authorKaracosta, Loukia
dc.contributor.authorKarimi, Mostafa
dc.contributor.authorKaski, Samuel
dc.contributor.authorKazanov, Marat
dc.contributor.authorKhamis, Abdullah M.
dc.contributor.authorKhan, Suleiman Ali
dc.contributor.authorKiani, Narsis A.
dc.contributor.authorKim, Allen
dc.contributor.authorKim, Jinhan
dc.contributor.authorKim, Juntae
dc.contributor.authorKim, Kiseong
dc.contributor.authorKim, Kyung
dc.contributor.authorKim, Sunkyu
dc.contributor.authorKim, Yongsoo
dc.contributor.authorKim, Yunseong
dc.contributor.authorKirk, Paul D.W.
dc.contributor.authorKitano, Hiroaki
dc.contributor.authorKlambauer, Gunter
dc.contributor.authorKnowles, David
dc.contributor.authorKo, Melissa
dc.contributor.authorKohn-Luque, Alvaro
dc.contributor.authorKooistra, Albert J.
dc.contributor.authorKuenemann, Melaine A.
dc.contributor.authorKuiper, Martin
dc.contributor.authorKurz, Christoph
dc.contributor.authorKwon, Mijin
dc.contributor.authorvan Laarhoven, Twan
dc.contributor.authorLaegreid, Astrid
dc.contributor.authorLederer, Simone
dc.contributor.authorLee, Heewon
dc.contributor.authorLee, Jeon
dc.contributor.authorLee, Yun Woo
dc.contributor.authorLepp_aho, Eemeli
dc.contributor.authorLewis, Richard
dc.contributor.authorLi, Jing
dc.contributor.authorLi, Lang
dc.contributor.authorLiley, James
dc.contributor.authorLim, Weng Khong
dc.contributor.authorLin, Chieh
dc.contributor.authorLiu, Yiyi
dc.contributor.authorLopez, Yosvany
dc.contributor.authorLow, Joshua
dc.contributor.authorLysenko, Artem
dc.contributor.authorMachado, Daniel
dc.contributor.authorMadhukar, Neel
dc.contributor.authorMaeyer, Dries De
dc.contributor.authorMalpartida, Ana Belen
dc.contributor.authorMamitsuka, Hiroshi
dc.contributor.authorMarabita, Francesco
dc.contributor.authorMarchal, Kathleen
dc.contributor.authorMarttinen, Pekka
dc.contributor.authorMason, Daniel
dc.contributor.authorMazaheri, Alireza
dc.contributor.authorMehmood, Arfa
dc.contributor.authorMehreen, Ali
dc.contributor.authorMichaut, Magali
dc.contributor.authorMiller, Ryan A.
dc.contributor.authorMitsopoulos, Costas
dc.contributor.authorModos, Dezso
dc.contributor.authorMoerbeke, Marijke Van
dc.contributor.authorMoo, Keagan
dc.contributor.authorMotsinger-Reif, Alison
dc.contributor.authorMovva, Rajiv
dc.contributor.authorMuraru, Sebastian
dc.contributor.authorMuratov, Eugene
dc.contributor.authorMushthofa, Mushthofa
dc.contributor.authorNagarajan, Niranjan
dc.contributor.authorNakken, Sigve
dc.contributor.authorNath, Aritro
dc.contributor.authorNeuvial, Pierre
dc.contributor.authorNewton, Richard
dc.contributor.authorNing, Zheng
dc.contributor.authorNiz, Carlos De
dc.contributor.authorOliva, Baldo
dc.contributor.authorOlsen, Catharina
dc.contributor.authorPalmeri, Antonio
dc.contributor.authorPanesar, Bhawan
dc.contributor.authorPapadopoulos, Stavros
dc.contributor.authorPark, Jaesub
dc.contributor.authorPark, Seonyeong
dc.contributor.authorPark, Sungjoon
dc.contributor.authorPawitan, Yudi
dc.contributor.authorPeluso, Daniele
dc.contributor.authorPendyala, Sriram
dc.contributor.authorPeng, Jian
dc.contributor.authorPerfetto, Livia
dc.contributor.authorPirro, Stefano
dc.contributor.authorPlevritis, Sylvia
dc.contributor.authorPoliti, Regina
dc.contributor.authorPoon, Hoifung
dc.contributor.authorPorta, Eduard
dc.contributor.authorPrellner, Isak
dc.contributor.authorPreuer, Kristina
dc.contributor.authorPujana, Miguel Angel
dc.contributor.authorRamnarine, Ricardo
dc.contributor.authorReid, John E.
dc.contributor.authorReyal, Fabien
dc.contributor.authorRichardson, Sylvia
dc.contributor.authorRicketts, Camir
dc.contributor.authorRieswijk, Linda
dc.contributor.authorRocha, Miguel
dc.contributor.authorRodriguez-Gonzalvez, Carmen
dc.contributor.authorRoell, Kyle
dc.contributor.authorRotroff, Daniel
dc.contributor.authorde Ruiter, Julian R.
dc.contributor.authorRukawa, Ploy
dc.contributor.authorSadacca, Benjamin
dc.contributor.authorSafikhani, Zhaleh
dc.contributor.authorSafitri, Fita
dc.contributor.authorSales-Pardo, Marta
dc.contributor.authorSauer, Sebastian
dc.contributor.authorSchlichting, Moritz
dc.contributor.authorSeoane, Jose A.
dc.contributor.authorSerra, Jordi
dc.contributor.authorShang, Ming Mei
dc.contributor.authorSharma, Alok
dc.contributor.authorSharma, Hari
dc.contributor.authorShen, Yang
dc.contributor.authorShiga, Motoki
dc.contributor.authorShin, Moonshik
dc.contributor.authorShkedy, Ziv
dc.contributor.authorShopsowitz, Kevin
dc.contributor.authorSinai, Sam
dc.contributor.authorSkola, Dylan
dc.contributor.authorSmirnov, Petr
dc.contributor.authorSoerensen, Izel Fourie
dc.contributor.authorSoerensen, Peter
dc.contributor.authorSong, Je Hoon
dc.contributor.authorSong, Sang Ok
dc.contributor.authorSoufan, Othman
dc.contributor.authorSpitzmueller, Andreas
dc.contributor.authorSteipe, Boris
dc.contributor.authorSuphavilai, Chayaporn
dc.contributor.authorTamayo, Sergio Pulido
dc.contributor.authorTamborero, David
dc.contributor.authorTang, Jing
dc.contributor.authorTanoli, Zia ur Rehman
dc.contributor.authorTarres-Deulofeu, Marc
dc.contributor.authorTegner, Jesper
dc.contributor.authorThommesen, Liv
dc.contributor.authorTonekaboni, Seyed Ali Madani
dc.contributor.authorTran, Hong
dc.contributor.authorTroyer, Ewoud De
dc.contributor.authorTruong, Amy
dc.contributor.authorTsunoda, Tatsuhiko
dc.contributor.authorTuru, Gábor
dc.contributor.authorTzeng, Guang Yo
dc.contributor.authorVerbeke, Lieven
dc.contributor.authorVidela, Santiago
dc.contributor.authorVis, Daniel
dc.contributor.authorVoronkov, Andrey
dc.contributor.authorVotis, Konstantinos
dc.contributor.authorWang, Ashley
dc.contributor.authorWang, Hong Qiang Horace
dc.contributor.authorWang, Po Wei
dc.contributor.authorwang, sheng
dc.contributor.authorWang, Wei
dc.contributor.authorWang, Xiaochen
dc.contributor.authorWang, Xin
dc.contributor.authorWennerberg, Krister
dc.contributor.authorWernisch, Lorenz
dc.contributor.authorWessels, Lodewyk
dc.contributor.authorvan Westen, Gerard J.P.
dc.contributor.authorWesterman, Bart A.
dc.contributor.authorWhite, Simon Richard
dc.contributor.authorWillighagen, Egon
dc.contributor.authorWurdinger, Tom
dc.contributor.authorXie, Lei
dc.contributor.authorXie, Shuilian
dc.contributor.authorXu, Hua
dc.contributor.authorYadav, Bhagwan
dc.contributor.authorYau, Christopher
dc.contributor.authorYeerna, Huwate
dc.contributor.authorYin, Jia Wei
dc.contributor.authorYu, Michael
dc.contributor.authorYu, Min Hwan
dc.contributor.authorYun, So Jeong
dc.contributor.authorZakharov, Alexey
dc.contributor.authorZamichos, Alexandros
dc.contributor.authorZanin, Massimiliano
dc.contributor.authorZeng, Li
dc.contributor.authorZenil, Hector
dc.contributor.authorZhang, Frederick
dc.contributor.authorZhang, Pengyue
dc.contributor.authorZhang, Wei
dc.contributor.authorZhao, Hongyu
dc.contributor.authorZhao, Lan
dc.contributor.authorZheng, Wenjin
dc.contributor.authorZoufir, Azedine
dc.contributor.authorZucknick, Manuela
dc.contributor.authorJang, In Sock
dc.contributor.authorGhazoui, Zara
dc.contributor.authorAghamirzaie, Delasa
dc.contributor.authorVogel, Robert
dc.contributor.authorNeto, Elias Chaibub
dc.contributor.authorNorman, Thea
dc.contributor.authorTang, Eric K.Y.
dc.contributor.authorGarnett, Mathew J.
dc.contributor.authorVeroli, Giovanni Y.Di
dc.contributor.authorFawell, Stephen
dc.contributor.authorAltarawy, Doaa
dc.contributor.authorAlves, Vinicius
dc.contributor.authorDry, Jonathan R.
dc.contributor.authorAnchang, Benedict
dc.date.accessioned2019-08-26T11:32:45Z
dc.date.available2019-08-26T11:32:45Z
dc.date.issued2019-06-17
dc.identifier.citationMenden, M. P., Wang, D., Mason, M. J., Szalai, B., Bulusu, K. C., … Saez-Rodriguez, J. (2019). Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen. Nature Communications, 10(1). doi:10.1038/s41467-019-09799-2
dc.identifier.doi10.1038/s41467-019-09799-2
dc.identifier.urihttp://hdl.handle.net/10754/656605
dc.description.abstractThe effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.
dc.description.sponsorshipWe thank the Genomics of Drug Sensitivity in Cancer and COSMIC teams at the Wellcome Trust Sanger Institute for help with the preparation of the molecular data, Denes Turei for help with Omnipath, and Katjusa Koler for help with matching drug names across combination screens. We thank AstraZeneca for funding and provision of data to the DREAM Consortium to run the challenge, and funding from the European Union Horizon 2020 research (under grant agreement No 668858 PrECISE to J.S.R.), the Joint Research Center for Computational Biomedicine (which is partially funded by Bayer AG) to J.S.R., National Institute for Health Research (NIHR) Sheffield Biomedical Research Center, Premium Postdoctoral Fellowship Program of the Hungarian Academy of Sciences. M.G lab is supported by Wellcome Trust (102696 and 206194)
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.urlhttp://www.nature.com/articles/s41467-019-09799-2
dc.rightsArchived with thanks to Nature Communications
dc.titleCommunity assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
dc.typeArticle
dc.contributor.departmentComputer Science Program
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentBioinformatics
dc.identifier.journalNature Communications
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionOncology, IMED Biotech Unit, AstraZeneca, Cambridge, SG8 6EH, UK
dc.contributor.institutionEuropean Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, CB10 1SD, UK
dc.contributor.institutionInstitute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Munich, D-85764, Germany
dc.contributor.institutionSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, S10 2TN, UK
dc.contributor.institutionSage Bionetworks, Seattle, WA, 98121, USA
dc.contributor.institutionDepartment of Physiology, Faculty of Medicine, Semmelweis University, Budapest, 1085, Hungary
dc.contributor.institutionRWTH Aachen University, Faculty of Medicine, Joint Research Center for Computational Biomedicine, Aachen, 52062, Germany
dc.contributor.institutionLaboratory of Molecular Physiology, Hungarian Academy of Sciences and Semmelweis University (MTA-SE), Budapest, 1085, Hungary
dc.contributor.institutionDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, 48109, USA
dc.contributor.institutionDepartment of Computer Science and Engineering, Korea University, Seoul, 02841, Korea
dc.contributor.institutionSAS Institute, Inc, Cary, NC, 27513, USA
dc.contributor.institutionDepartment of Computer Science and Engineering, University of Nevada, Reno, 89557, USA
dc.contributor.institutionIndependent Consultant in Computational Biology, Owkin, Inc., New York, NY, 10022, USA
dc.contributor.institutionDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, 77843, USA
dc.contributor.institutionDepartment of Bioinformatics - BiGCaT NUTRIM Maastricht University, Maastricht, 6229, ER, The Netherlands
dc.contributor.institutionDivision of Molecular Carcinogenesis NKI, Amsterdam, 1066, CX, The Netherlands
dc.contributor.institutionFaculty of EEMCS, Delft University of Technology, Delft, 2628, CD, The Netherlands
dc.contributor.institutionGenetics Bioinformatics and Computational Biology Virginia Tech, Blacksburg, VA, 24061, USA
dc.contributor.institutionInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, FI-00014, Finland
dc.contributor.institutionBioinformatics Research Center North Carolina State University, Raleigh, NC, 27695-7566, USA
dc.contributor.institutionThe Institute of Cancer Research, London, SW3 6JB, UK
dc.contributor.institutionCentre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK
dc.contributor.institutionDepartment of Computer Science Virginia Tech, Blacksburg, VA, 24061, USA
dc.contributor.institutionAlexandria University, Alexandria, 21500, Egypt
dc.contributor.institutionEshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, 27599, USA
dc.contributor.institutionDepartment of Bioinformatics, Igenomix SL, Valencia, 46980, Spain
dc.contributor.institutionDepartment of Radiology, Stanford University, Drive, Stanford, 94305, USA
dc.contributor.institutionBioinformatics Research Center, Department of Chemistry, Department of Statistics, North Carolina State University, Raleigh, NC, 27695, USA
dc.contributor.institutionLeloir Institute, Buenos Aires, C1405 BWE, Argentina
dc.contributor.institutionUniversity of Toronto, Toronto, ON M5S, Canada
dc.contributor.institutionUnit of Computational Medicine, Department of Medicine, Solna SciLifeLab Center for Molecular Medicine Karolinska Institute, Solna, SE-171 76, Sweden
dc.contributor.institutionINSERM U1068, Marseille, 13005, France
dc.contributor.institutionInstitut Paoli-Calmettes, Marseille, 13009, France
dc.contributor.institutionAix-Marseille University, 13007, Marseille, France
dc.contributor.institutionCNRS UMR7258, Marseille, 13273, France
dc.contributor.institutionCentre Biological Engineering (CEB), University of Minho, Braga, 4710-057, Portugal
dc.contributor.institutionInstitut HyperCube, Paris, 92907, France
dc.contributor.institutionComputational and Systems Biology, Genome Institute of Singapore, Singapore, 138672, Singapore
dc.contributor.institutionIndiana University School of Medicine, Indianapolis, 46202, USA
dc.contributor.institutionCenter for Integrative Medical Sciences RIKEN Japan, Kobe, Hyogo, 650-0047, Japan
dc.contributor.institutionCancer Genomics Netherlands, Utrecht, 3584 CG, Netherlands
dc.contributor.institutionComputer Laboratory, University of Cambridge, Cambridge, CB3 0FD, UK
dc.contributor.institutionConstellation Pharmaceuticals, Cambridge, 2142, USA
dc.contributor.institutionCIMUS University of Santiago de Compostela, La Coruña, 15001, Spain
dc.contributor.institutionBioinformatics and Computational Biology Unit, Department of Biology, University of Rome Tor Vergata, Rome, 00133, Italy
dc.contributor.institutionDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, SE-171 76, Sweden
dc.contributor.institutionDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, 25123, Italy
dc.contributor.institutionCentre de Regulacio Genomica (CRG), Barcelona Institute for Science and Technology, Barcelona, 08036, Spain
dc.contributor.institutionDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA
dc.contributor.institutionDepartment of Biology, University of Rome Tor Vergata, Rome, 00133, Italy
dc.contributor.institutionDepartment of Computer Engineering, Ege University Turkey, Metro İstasyonu, 35100, Turkey
dc.contributor.institutionUniversity of Texas Health Science Center, Houston, 77030, USA
dc.contributor.institutionTexas A&M University, Station, College Station, TX, 77843, USA
dc.contributor.institutionCase Western University, Cleveland, 44106, USA
dc.contributor.institutionPrincess Margaret Cancer Centre, Toronto, M5G 2C1, Canada
dc.contributor.institutionDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea
dc.contributor.institutionDepartment of Medical Information, Kongju Nationtional University, Gongju, 32588, South Korea
dc.contributor.institutionBio-Synergy Research Center, Daejeon, 02451, Republic of Korea
dc.contributor.institutionUniversity of Washington Tacoma, Tacoma, 98402, USA
dc.contributor.institutionDepartement de Biologie Structurale et Chimie Institut Pasteur Unite de Bioinformatique Structurale CNRS UMR, 3825, Paris, France
dc.contributor.institutionClinical Bioinformatic Area Fundacion Progreso y Salud CDCA Hospital Virgen del Rocio, Sevilla, 41092, Spain
dc.contributor.institutionStanford University, Stanford, 94305, USA
dc.contributor.institutionKU Leuven, Leuven, 3000, Belgium
dc.contributor.institutionMax Planck Institute for Developmental Biology, Tuebingen, 72076, Germany
dc.contributor.institutionDepartment of Computer Science, Wayne State University Michigan, Detroit, 48202, USA
dc.contributor.institutionDepartment of Obstetrics and Gynecology, Wayne State University Michigan, Detroit, 48202, USA
dc.contributor.institutionCERTH-ITI, Thessaloniki, GR 5700, Greece
dc.contributor.institutionInstitute of Data Science, Maastricht University, Maastricht, 6229 ER, Netherlands
dc.contributor.institutionAl-Azhar University, Cairo, 11651, Egypt
dc.contributor.institutionNational Research Centre, Cairo, 12622, Egypt
dc.contributor.institutionNile University, Cairo, 12622, Egypt
dc.contributor.institutionDivision of Medicinal Chemistry, AIMMS Vrije Universiteit, Amsterdam, 1081 HZ, The Netherlands
dc.contributor.institutionLaSIGE Faculdade de Ciencias Universidade de Lisboa Portugal, Lisboa, 1749-016, Portugal
dc.contributor.institutionUniversity of A Coruna, Coruña, 15001, Spain
dc.contributor.institutionCenter for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA, 92093, USA
dc.contributor.institutionNorwegian University of Science and Technology, Trondheim, 7491, Norway
dc.contributor.institutionSt. Olav’s University Hospital, Trondheim, 7030, Norway
dc.contributor.institutionTexas State University, San Marcos Texas, San Marcos, 78666, USA
dc.contributor.institutionUniversity of Oxford, Oxford, OX1 2JD, UK
dc.contributor.institutionBioinformatics Research Center, Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA
dc.contributor.institutionOslo Centre for Biostatistics and Epidemiology, University of Oslo and Oslo University Hospital Norway, Oslo, 0317, Norway
dc.contributor.institutionDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, 999077, Hong Kong
dc.contributor.institutionYale University, New Haven, 06520, USA
dc.contributor.institutionProgram for Evolutionary Dynamics, Harvard University, Cambridge, 02138, USA
dc.contributor.institutionInstitut Curie Inserm U900, Paris, 75248, France
dc.contributor.institutionThe Systems Biology Institute Tokyo, Tokyo, 141-0022, Japan
dc.contributor.institutionDepartment of Computer Science Aalto University, Espoo, 02150, Finland
dc.contributor.institutionDepartament d’Enginyeria, Quimica Universitat Rovira i Virgili, Tarragona, 43007, Spain
dc.contributor.institutionSanford Burnham Prebys Medical Discovery Institute, Jolla, 92037, USA
dc.contributor.institutionHospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
dc.contributor.institutionMucosal and Salivary Biology Division King’s College London Dental Institute, London, SE1 9RT, UK
dc.contributor.institutionCollege of Engineering, Koc University, Istanbul, 34450, Turkey
dc.contributor.institutionSchool of Medicine, Koc University, Istanbul, 34450, Turkey
dc.contributor.institutionMRC Biostatistics Unit University of Cambridge, Cambridge, CB2 0SR, UK
dc.contributor.institutionUniversity of Washington, Seattle, WA, 98195, USA
dc.contributor.institutionICREA, Barcelona, 08010, Spain
dc.contributor.institutionJoint IRB-BSC-CRG Program in Computational Biology Institute for Research in Biomedicine, Barcelona, 08028, Spain
dc.contributor.institutionPrincess Margaret Cancer Centre, University Health Network, Toronto, M5G 2C1, ON, Canada
dc.contributor.institutionPh.D. Program in Computer Science, The Graduate Center, The City University of New York, New York, 10016, USA
dc.contributor.institutionDepartment of Mathematics University of Oslo, Oslo, 0371, Norway
dc.contributor.institutionInstitute of Machine Learning Johannes Kepler University Linz, Linz, 4040, Austria
dc.contributor.institutionUniversity of Wisconsin, Madison, 53706, USA
dc.contributor.institutionDepartment of Tumor Biology Institute for Cancer Research, Oslo University Hospital Norway, Oslo, 0424, Norway
dc.contributor.institutionDepartment of Informatics University of Oslo, Oslo, 0316, Norway
dc.contributor.institutionWellcome Trust Centre for Human Genetics University of Oxford, Oxford, OX3 7BN, UK
dc.contributor.institutionBioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, 92093, USA
dc.contributor.institutionUniversity of Minnesota, Minneapolis, 55455, USA
dc.contributor.institutionDepartment of Computer Science and Statistics, Daegu University, Daegu, 38453, South Korea
dc.contributor.institutionDepartment Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
dc.contributor.institutionDepartment of Computer Science, The University of Suwon, Suwon, 16499, Republic of Korea
dc.contributor.institutionDepartment of Biomedical Informatics, Columbia University in the City of New York, New York, 10032, USA
dc.contributor.institutionSchool of Statistics Shandong, University of Finance and Economics, Jinan, 250000, China
dc.contributor.institutionDepartment of Computer Science, Hunter College, The City University of New York, New York, NY, 10065, USA
dc.contributor.institutionDepartment of Biostatistics, School of Public Health Shandong University China, Shandong, 250012, China
dc.contributor.institutionSkolkovo Institute of Science and Technology, Moscow, 121205, Russia
dc.contributor.institutionA.A.Kharkevich Institute for Information Transmission Problems, Moscow, 127051, Russia
dc.contributor.institutionAlgorithmic Dynamics Lab Unit of Computational Medicine, Department of Medicine Solna, SciLifeLab Center for Molecular Medicine Karolinska Institute, Solna, SE-171 76, Sweden
dc.contributor.institutionStandigm Inc, Seoul, 06250, Korea
dc.contributor.institutionDepartment of Bioengineering, University of Washington, Seattle, 98195, USA
dc.contributor.institutionDivision of Oncogenomics NKI, Amsterdam, 1066, CX, The Netherlands
dc.contributor.institutionDepartment of Genetics, Stanford University, Stanford, 94305, USA
dc.contributor.institutionDepartment of Cancer Biology, Stanford University Stanford, Stanford, 94305, USA
dc.contributor.institutionOslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, Oslo, 0317, Norway
dc.contributor.institutionHelmholtz Zentrum Munchen Institute of Health Economics and Health Care Management, Neuherberg, 85764, Germany
dc.contributor.institutionData Science Radboud University, Nijmegen, 6525, Netherlands
dc.contributor.institutionThe Ohio State University College of Medicine, Department of Biomedical Informatics, Columbus, 43210, USA
dc.contributor.institutionDepartment of Medicine, University of Cambridge, Cambridge, CB2 0SP, UK
dc.contributor.institutionCentre for Computational Biology Duke-NUS, Medical School Singapore, Singapore, 169857, Singapore
dc.contributor.institutionSingHealth Duke-NUS Institute of Precision Medicine Singapore, Singapore, 169857, Singapore
dc.contributor.institutionCarnegie Mellon University, Pittsburgh, 15213, USA
dc.contributor.institutionDepartment of Medical Science, Mathematics Medical Research Institute Tokyo Medical and Dental University, Tokyo, 113-8510, Japan
dc.contributor.institutionCREST JST, Tokyo, 102-0076, Japan
dc.contributor.institutionWeill Cornell Medicine, New York, NY, 10065, USA
dc.contributor.institutionGhent University, Gent, 9000, Belgium
dc.contributor.institutionBioinformatics Center Institute for Chemical Research Kyoto University, Kyoto, 611-0011, Japan
dc.contributor.institutionHelsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University Finland, Espoo, 02150, Finland
dc.contributor.institutionUniversity of Turku, Turku, 20500, Finland
dc.contributor.institutionHelsinki University, Helsinki, 00100, Finland
dc.contributor.institutionInteruniversity Institute of Bioinformatics in Brussels, Ixelles, 1050, Belgium
dc.contributor.institutionGhent University Bogor Agricultural University, Gent, 9000, Belgium
dc.contributor.institutionInstitut de Mathematiques de Toulouse, Universite Paul Sabatier, Toulouse, 31400, France
dc.contributor.institutionUniversity of Cambridge, Cambridge, CB2 8PQ, UK
dc.contributor.institutionTexas Tech University, Lubbock, 79409, USA
dc.contributor.institutionStructural Bioinformatics Group GRIB IMIM, Department of Experimental and Life Sciences, Universitat Pompeu Fabra Barcelona, Catalonia, 08041, Spain
dc.contributor.institutionMachine Learning Group (MLG), Department d’Informatique, Universite libre de Bruxelles (ULB), Brussels, 1050, Belgium
dc.contributor.institutionHarvard University, Cambridge, 02138, USA
dc.contributor.institutionUniversity of Illinois at Urbana-Champaign Urbana, Champaign, 61820, USA
dc.contributor.institutionMicrosoft Research Redmond, Redmond, 98052, USA
dc.contributor.institutionCambridge Rindge and Latin High School, Cambridge, 02138, USA
dc.contributor.institutionCatalan Institute of Oncology (ICO), Barcelona, 199 08908, Spain
dc.contributor.institutionBellvitge Biomedical Biomedical Research Institute (IDIBELL), Barcelona, 199 08908, Spain
dc.contributor.institutionInstitut Curie RT2 Lab, Paris, 75248, France
dc.contributor.institutionDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, 94720, USA
dc.contributor.institutionDivision of Molecular Pathology NKI, Amsterdam, 1066, CX, The Netherlands
dc.contributor.institutionKyungpook National University, Daegu, 41566, South Korea
dc.contributor.institutionFOM University of Applied Sciences, Essen, 45127, Germany
dc.contributor.institutionInstitute for Integrated and Intelligent Systems Griffith University, Mount Gravatt, QLD, 4111, Australia
dc.contributor.institutionUniversity of the South Pacific Fiji, Suva, Fiji
dc.contributor.institutionDepartment of Electrical Electronic and Computer Engineering, Gifu University, Gifu, 501-1193, Japan
dc.contributor.institutionCenter for Statistics, Hasselt University Belgium, Hasselt, 3590, Belgium
dc.contributor.institutionFaculty of Medicine, University of British Columbia, Kelowna, V1Y 1T3, Canada
dc.contributor.institutionCenter for Quantitative Genetics and Genomics, Department of Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark
dc.contributor.institutionTechnische Universitat Munchen, München, 80333, Germany
dc.contributor.institutionDepartment of Computer Science, National University of Singapore, Singapore, 117417, Singapore
dc.contributor.institutionResearch Unit on Biomedical Informatics, University Pompeu Fabra UPF, Barcelona, 08041, Spain
dc.contributor.institutionCancer Hospital of Chinese Academy of Sciences, Hefei, 230031, China
dc.contributor.institutionDrug Discovery and Safety Leiden, Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden, 2333, CC, The Netherlands
dc.contributor.institutionDepartment of Neurosurgery, Cancer Center, Amsterdam, 1012, WX, The Netherlands
dc.contributor.institutionDepartment of Computer Science, Hunter College and The Graduate Center, The City University of New York, New York, NY, 10016, USA
dc.contributor.institutionHematology Research Unit Helsinki, Department of Clinical Chemistry and Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, 00029, Finland
dc.contributor.institutionInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, B15 2SY, UK
dc.contributor.institutionUniversity of California, San Diego, SD, 92093, USA
dc.contributor.institutionNational Center for Advancing Translational Sciences National Institutes of Health, Rockville, MD, 20892, USA
dc.contributor.institutionUniversidad Politecnica de Madrid, Madrid, 28040, Spain
dc.contributor.institutionOxford Immune Algorithmics Ltd, Oxford, RG1 3EU, UK
dc.contributor.institutionIndiana University - Purdue University, Indianapolis, 47907, USA
dc.contributor.institutionDepartment of Electronic Engineering, City University of Hong Kong, Hong Kong, 999077, Hong Kong
dc.contributor.institutionIBM Thomas J. Watson Research Center, Yorktown Heights, New York, 10598, USA
dc.contributor.institutionWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
dc.contributor.institutionEarly Clinical Development, IMED Biotech Unit, AstraZeneca, Cambridge, SG8 6EH, UK
dc.contributor.institutionOncology, IMED Biotech Unit, AstraZeneca, R&D Boston, Waltham, MA, 02451, USA
dc.contributor.institutionDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, 10029, USA
dc.contributor.institutionHeidelberg University, Faculty of Medicine, Institute for Computational Biomedicine, Bioquant, 69120, Heidelberg, Germany
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
pubs.publication-statusPublished
kaust.personAlam, Tanvir
kaust.personAllam, Amin
kaust.personBa Alawi, Wail
kaust.personBajic, Vladimir B.
kaust.personBougouffa, Salim
kaust.personKhamis, Abdullah M.
kaust.personTegner, Jesper
refterms.dateFOA2019-08-26T11:32:46Z
dc.date.published-online2019-06-17
dc.date.published-print2019-12


Files in this item

Thumbnail
Name:
s41467-019-09799-2.pdf
Size:
1.574Mb
Format:
PDF
Description:
Main article

This item appears in the following Collection(s)

Show simple item record