Lactate and pyruvate promote cellular stress resistance and longevity through ROS signaling.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Laboratory for Cellular Imaging and Energetics, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia
Permanent link to this recordhttp://hdl.handle.net/10754/656584
MetadataShow full item record
AbstractL-lactate, for long considered a glycolytic end-product, is now recognized as an important energy substrate. Moreover, it appears that its role is not limited to energy production but also as a signal for neuroprotection and synaptic plasticity. Using a model of neuroblastoma cells and the nematode C. elegans we investigated the cellular mechanisms underlying this protective role of L-lactate. We found that L-lactate promotes a mild Reactive Oxygen Species (ROS) induction that translates into activation of antioxidant defenses and pro-survival pathways such as PI3K/AKT and Endoplasmic Reticulum (ER) chaperones. This hormetic mechanism provides protection against oxidative stress in both cells and nematodes. Furthermore, a mild ROS induction by lactate also promotes longevity in C. elegans.
CitationTauffenberger, A., Fiumelli, H., Almustafa, S., & Magistretti, P. J. (2019). Lactate and pyruvate promote cellular stress resistance and longevity through ROS signaling. doi:10.1101/542316
SponsorsWe thank Magdalena Julkowska, Nadia Steiner and Lorène Mottier for their technical assistance. We want to thank Dr. J. Alex Parker initial support in the project and RNAi clones and Dr. Christian Frøkjær-Jensen for critical reading of the manuscript. Thanks to the C. elegans Genetic Center for the different strains used in this study. Support for this study was provided by King Abdullah University of Science and Technology.
PublisherCold Spring Harbor Laboratory