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    The Caenorhabditis elegans Transgenic Toolbox

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    Type
    Article
    Authors
    Nance, Jeremy
    Frøkjær-Jensen, Christian cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2019-08-12
    Online Publication Date
    2019-08-12
    Print Publication Date
    2019-08
    Permanent link to this record
    http://hdl.handle.net/10754/656565
    
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    Abstract
    The power of any genetic model organism is derived, in part, from the ease with which gene expression can be manipulated. The short generation time and invariant developmental lineage have made Caenorhabditis elegans very useful for understanding, e.g., developmental programs, basic cell biology, neurobiology, and aging. Over the last decade, the C. elegans transgenic toolbox has expanded considerably, with the addition of a variety of methods to control expression and modify genes with unprecedented resolution. Here, we provide a comprehensive overview of transgenic methods in C. elegans, with an emphasis on recent advances in transposon-mediated transgenesis, CRISPR/Cas9 gene editing, conditional gene and protein inactivation, and bipartite systems for temporal and spatial control of expression.
    Citation
    Nance, J., & Frøkjær-Jensen, C. (2019). The Caenorhabditis elegans Transgenic Toolbox. Genetics, 212(4), 959–990. doi:10.1534/genetics.119.301506
    Sponsors
    The authors thank E. Jane Hubbard, M. Wayne Davis,Te-Wen Lo, Jordan Ward, Han Wang, and members of their laboratories for thoughtful comments on the review. Related research in the authors’ laboratories is supported by grants from the National Institutes of Health (R21HD088779 and R35GM118081 to J.N.) and King Abdullah University of Science and Technology (KAUST) (to C.F.-J.)
    Publisher
    Genetics Society of America
    Journal
    Genetics
    DOI
    10.1534/genetics.119.301506
    Additional Links
    http://www.genetics.org/lookup/doi/10.1534/genetics.119.301506
    ae974a485f413a2113503eed53cd6c53
    10.1534/genetics.119.301506
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program

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