Optimization of a 3D bioprinting process using ultrashort peptide bioinks
Ramirez Calderon, Gustavo
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Computational Bioscience Research Center (CBRC)
Engineering / Metrology
Environmental Science and Engineering Program
KAUST Catalysis Center (KCC)
Laboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah, University of Science and Technology, Thuwal, Saudi Arabia
Permanent link to this recordhttp://hdl.handle.net/10754/656488
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AbstractThe field of three-dimensional (3D) bioprinting is rapidly emerging as an additive manufacturing method for tissue and organ fabrication. The demand for tissues and organ transplants is ever increasing, although donors are not as readily available. Consequently, tissue engineering is gaining much attention to alleviate this problem. The process of achieving well-structured 3D bioprinted constructs using hydrogel bioinks depends on symmetrical precision, regulated flow rates, and viability of cells. Even with the mentioned parameters optimized, the printed structures need additional refining by removing excessive liquids, as peptide hydrogel bioprints encapsulate water. However, it is challenging to eliminate the confined fluids without compromising the printing process. In this paper, we introduced a vacuum system to our 3D bioprinting robotic arm and thus optimized the printing quality for complex and refined 3D scaffolds. Moreover, the proposed vacuum system supports printing with cells. Our results show improved printing resolution which facilitates the printing of higher and more stable structures.
CitationKhan, Z., Kahin, K., Rauf, S., Ramirez-Calderon, G., Papagiannis, N., Abdulmajid, M., & Hauser, C. (2018). Optimization of a 3D Bioprinting Process Using Ultrashort Peptide Bioinks. International Journal of Bioprinting, 5(1). doi:10.18063/ijb.v5i1.173
SponsorsThe research was supported by funding from King Abdullah University for Science and Technology (KAUST).
PublisherWhioce Publishing Pte Ltd
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.