Metal coordination of thymosin β4: Chemistry and possible implications
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ArticleAuthors
Lachowicz, Joanna IzabelaJaremko, Mariusz

Jaremko, Lukasz

Pichiri, Giuseppina
Coni, Pierpaolo
Piludu, Marco
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Date
2019-06-25Online Publication Date
2019-06-25Print Publication Date
2019-10Embargo End Date
2021-06-25Permanent link to this record
http://hdl.handle.net/10754/656445
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Thymosin β4 (Tβ4) was first isolated in the ‘60ies from calf thymus and was initially perceived as a thymic hormone with immunological effects on lymphocytes. It was then identified as a G-actin binding protein, featuring numerous functions in the human body including blood clothing, tissue regeneration, angiogenesis and tumor metastasis. Tβ4 is also involved in anti-inflammatory and neurodegenerative processes. The exact mechanisms of action of Tβ4 are still unknown, and the binding of the G-actin protein cannot itself explain the multi-activity of Tβ4. We hypothesize that the property of Tβ4 regulating the numerous physiological processes involving Tβ4, is its essential metal – binding ability.Citation
Lachowicz, J. I., Jaremko, M., Jaremko, L., Pichiri, G., Coni, P., & Piludu, M. (2019). Metal coordination of thymosin β4: Chemistry and possible implications. Coordination Chemistry Reviews, 396, 117–123. doi:10.1016/j.ccr.2019.06.008Publisher
Elsevier BVJournal
Coordination Chemistry ReviewsAdditional Links
https://linkinghub.elsevier.com/retrieve/pii/S0010854519301833ae974a485f413a2113503eed53cd6c53
10.1016/j.ccr.2019.06.008