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    Metal coordination of thymosin β4: Chemistry and possible implications

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    Thumbnail
    Name:
    CCR_2019_134_Revision 1_V01.pdf
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    5.504Mb
    Format:
    PDF
    Description:
    Accepted Manuscript
    Embargo End Date:
    2021-06-25
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    Supplementay material thymosine b4 Review_Revised.docx
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    187.9Kb
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    Microsoft Word 2007
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    Supplemental files
    Embargo End Date:
    2021-06-25
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    Type
    Article
    Authors
    Lachowicz, Joanna Izabela
    Jaremko, Mariusz cc
    Jaremko, Lukasz cc
    Pichiri, Giuseppina
    Coni, Pierpaolo
    Piludu, Marco
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2019-06-25
    Online Publication Date
    2019-06-25
    Print Publication Date
    2019-10
    Embargo End Date
    2021-06-25
    Permanent link to this record
    http://hdl.handle.net/10754/656445
    
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    Abstract
    Thymosin β4 (Tβ4) was first isolated in the ‘60ies from calf thymus and was initially perceived as a thymic hormone with immunological effects on lymphocytes. It was then identified as a G-actin binding protein, featuring numerous functions in the human body including blood clothing, tissue regeneration, angiogenesis and tumor metastasis. Tβ4 is also involved in anti-inflammatory and neurodegenerative processes. The exact mechanisms of action of Tβ4 are still unknown, and the binding of the G-actin protein cannot itself explain the multi-activity of Tβ4. We hypothesize that the property of Tβ4 regulating the numerous physiological processes involving Tβ4, is its essential metal – binding ability.
    Citation
    Lachowicz, J. I., Jaremko, M., Jaremko, L., Pichiri, G., Coni, P., & Piludu, M. (2019). Metal coordination of thymosin β4: Chemistry and possible implications. Coordination Chemistry Reviews, 396, 117–123. doi:10.1016/j.ccr.2019.06.008
    Publisher
    Elsevier BV
    Journal
    Coordination Chemistry Reviews
    DOI
    10.1016/j.ccr.2019.06.008
    Additional Links
    https://linkinghub.elsevier.com/retrieve/pii/S0010854519301833
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ccr.2019.06.008
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program

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