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dc.contributor.authorEsau, Luke
dc.contributor.authorZhang, Guishan
dc.contributor.authorSagar, Sunil
dc.contributor.authorStingl, Ulrich
dc.contributor.authorBajic, Vladimir B.
dc.contributor.authorKaur, Mandeep
dc.date.accessioned2019-08-05T05:34:21Z
dc.date.available2019-08-05T05:34:21Z
dc.date.issued2019-06-20
dc.identifier.citationEsau, L., Zhang, G., Sagar, S., Stingl, U., Bajic, V. B., & Kaur, M. (2019). Mining the deep Red-Sea brine pool microbial community for anticancer therapeutics. BMC Complementary and Alternative Medicine, 19(1). doi:10.1186/s12906-019-2554-0
dc.identifier.doi10.1186/s12906-019-2554-0
dc.identifier.urihttp://hdl.handle.net/10754/656338
dc.description.abstractBACKGROUND: Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptations to these harsh conditions require a large suite of secondary metabolites, these microbes have a huge potential as a source of novel anticancer molecules. METHODS:A total of 60 ethyl-acetate extracts of newly isolated strains from extreme environments of the Red-Sea were isolated and tested against several human cancer cell lines for potential cytotoxic and apoptotic activities. RESULTS: Isolates from the Erba brine-pool accounted for 50% of active bacterial extracts capable of inducing 30% or greater inhibition of cell growth. Among the 60 extracts screened, seven showed selectivity towards triple negative BT20 cells compared to normal fibroblasts. CONCLUSION: In this study, we identified several extracts able to induce caspase-dependent apoptosis in various cancer cell lines. Further investigations and isolation of the active compounds of these Red Sea brine pool microbes may offer a chemotherapeutic potential for cancers with limited treatment options.
dc.description.sponsorshipAuthors want to thank Dr. Andre Antunes and Dr. Tyas Hikmawan for collecting samples.
dc.description.sponsorshipFunding: Authors thank SEDCO for funding this research.
dc.publisherSpringer Nature
dc.relation.urlhttps://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-019-2554-0
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleMining the deep Red-Sea brine pool microbial community for anticancer therapeutics.
dc.typeArticle
dc.contributor.departmentNGS, qPCR and Single Cell Genomics
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentOffice of the VP
dc.contributor.departmentMarine Science Program
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.identifier.journalBMC complementary and alternative medicine
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionKey Laboratory of Microbial Resources Collection and Preservation, Ministry of Agriculture, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, 100081, People's Republic of China.
kaust.personEsau, Luke
kaust.personSagar, Sunil
kaust.personStingl, Ulrich
kaust.personBajic, Vladimir B.
kaust.personKaur, Mandeep
refterms.dateFOA2019-08-05T05:35:22Z
dc.date.published-online2019-06-20
dc.date.published-print2019-12


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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.