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dc.contributor.authorMutschler, Isabella
dc.contributor.authorHänggi, Jürgen
dc.contributor.authorFrei, Manuela
dc.contributor.authorLieb, Roselind
dc.contributor.authorgrosse Holforth, Martin
dc.contributor.authorSeifritz, Erich
dc.contributor.authorSpinelli, Simona
dc.date.accessioned2019-07-31T13:09:42Z
dc.date.available2019-07-31T13:09:42Z
dc.date.issued2019-06-22
dc.identifier.citationMutschler, I., Hänggi, J., Frei, M., Lieb, R., grosse Holforth, M., Seifritz, E., & Spinelli, S. (2019). Insular volume reductions in patients with major depressive disorder. Neurology, Psychiatry and Brain Research, 33, 39–47. doi:10.1016/j.npbr.2019.06.002
dc.identifier.doi10.1016/j.npbr.2019.06.002
dc.identifier.urihttp://hdl.handle.net/10754/656271
dc.description.abstractBackground: Major Depressive Disorder (MDD) is one of the most common mental disorders. Converging evidence suggests that the insula plays an important role in the pathophysiology of MDD. Little is known regarding in which insula subregion volume alterations occur in patients with MDD. Methods: We analyzed voxel-based morphometry in T1-weighted MRI scans of unmedicated DSM-IV MDD patients (n = 26) and in age, education, and sex matched healthy controls (HC, n = 26). Furthermore, we performed a quantitative meta-analysis across 14 structural MRI MDD studies by applying the anatomical likelihood estimation technique to identify concordant volume reductions in MDD in the insula cortex. Results: We found significantly reduced grey matter volumes (GMV) in patients with MDD compared to HCs in the left mid-insula and in the right and left caudate nucleus. The left mid-insular volume reduction in our sample was consistent with the coordinate-based meta-analysis results. Conclusions: The findings highlight the role of the mid-insula in the psychopathology of MDD. The mid-insula subregion might be associated with reduced interoceptive abilities in patients with MDD that is the ability to process information of “how the body feels”. In addition, the caudate nucleus has been described as being part of a network that mediates emotional and motivational processes which seems to be affected in MDD.
dc.description.sponsorshipWe gratefully acknowledge financial support by the Freiwillige Akademische Gesellschaft (FAG) Basel, Switzerland to IM.
dc.publisherElsevier BV
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S094195001930048X
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Neurology Psychiatry and Brain Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neurology Psychiatry and Brain Research, [[Volume], [Issue], (2019-06-22)] DOI: 10.1016/j.npbr.2019.06.002 . © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMajor depressive disorder
dc.subjectInsula
dc.subjectVoxel-based morphometry
dc.subjectMeta-analysis
dc.subjectInteroception
dc.subjectGrey matter volume
dc.titleInsular volume reductions in patients with major depressive disorder
dc.typeArticle
dc.contributor.departmentAnimal Facility
dc.identifier.journalNeurology Psychiatry and Brain Research
dc.rights.embargodate2020-06-22
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Psychology, Clinical Psychology and Epidemiology, University of Basel, Basel, Switzerland
dc.contributor.institutionDivision Neuropsychology, Department of Psychology, University of Zurich, Zurich, Switzerland
dc.contributor.institutionDepartment of Psychology, University of Bern, Switzerland
dc.contributor.institutionPsychosomatic Competence Center, Department of Neurology, Inselspital, Bern, Switzerland
dc.contributor.institutionDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland
kaust.personSpinelli, Simona
refterms.dateFOA2020-06-22T00:00:00Z
dc.date.published-online2019-06-22
dc.date.published-print2019-09


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NOTICE: this is the author’s version of a work that was accepted for publication in Neurology Psychiatry and Brain Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neurology Psychiatry and Brain Research, [[Volume], [Issue], (2019-06-22)] DOI: 10.1016/j.npbr.2019.06.002 . © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as NOTICE: this is the author’s version of a work that was accepted for publication in Neurology Psychiatry and Brain Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neurology Psychiatry and Brain Research, [[Volume], [Issue], (2019-06-22)] DOI: 10.1016/j.npbr.2019.06.002 . © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/