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dc.contributor.authorCui, Guoxin
dc.contributor.authorLiew, Yi Jin
dc.contributor.authorLiew, Yi Jin
dc.contributor.authorLi, Yong
dc.contributor.authorLi, Yong
dc.contributor.authorKharbatia, Najeh M.
dc.contributor.authorKharbatia, Najeh M.
dc.contributor.authorZahran, Noura Ibrahim Omar
dc.contributor.authorZahran, Noura Ibrahim Omar
dc.contributor.authorEmwas, Abdul-Hamid M.
dc.contributor.authorEmwas, Abdul-Hamid M.
dc.contributor.authorEguiluz, Victor M.
dc.contributor.authorEguiluz, Victor M.
dc.contributor.authorAranda, Manuel
dc.contributor.authorAranda, Manuel
dc.date.accessioned2019-07-15T12:56:48Z
dc.date.available2019-07-15T12:56:48Z
dc.date.issued2019-06-24
dc.identifier.doi10.1371/journal.pgen.1008189
dc.identifier.urihttp://hdl.handle.net/10754/656034
dc.description.abstractThe metabolic symbiosis with photosynthetic algae allows corals to thrive in the oligotrophic environments of tropical seas. Different aspects of this relationship have been investigated using the emerging model organism Aiptasia. However, many fundamental questions, such as the nature of the symbiotic relationship and the interactions of nutrients between the partners remain highly debated. Using a meta-analysis approach, we identified a core set of 731 high-confidence symbiosis-associated genes that revealed host-dependent recycling of waste ammonium and amino acid synthesis as central processes in this relationship. Subsequent validation via metabolomic analyses confirmed that symbiont-derived carbon enables host recycling of ammonium into nonessential amino acids. We propose that this provides a regulatory mechanism to control symbiont growth through a carbon-dependent negative feedback of nitrogen availability to the symbiont. The dependence of this mechanism on symbiont-derived carbon highlights the susceptibility of this symbiosis to changes in carbon translocation, as imposed by environmental stress.
dc.description.sponsorshipFunding: This work was supported by KAUST baseline funds to MA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.description.sponsorshipAcknowledgments: We would like to thank Prof. John Pringle, Dr. Jit Ern Chen, and Maha J. Cziesielski for valuable comments on our manuscript.
dc.publisherPublic Library of Science (PLoS)
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pgen.1008189
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleHost-dependent nitrogen recycling as a mechanism of symbiont control in Aiptasia
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience
dc.contributor.departmentBioscience Program
dc.contributor.departmentMarine Science Program
dc.contributor.departmentMarine Science and Engineering
dc.contributor.departmentNMR
dc.contributor.departmentOrganics
dc.contributor.departmentRed Sea Research Center
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.identifier.journalPLOS Genetics
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionInstituto de Física Interdisciplinar y Sistemas Complejos IFISC (CSIC-UIB), Palma de Mallorca, Spain
kaust.personCui, Guoxin
kaust.personLiew, Yi Jin
kaust.personLi, Yong
kaust.personKharbatia, Najeh M.
kaust.personZahran, Noura Ibrahim Omar
kaust.personEmwas, Abdul-Hamid M.
kaust.personAranda, Manuel
refterms.dateFOA2019-07-15T12:59:48Z


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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.