• Login
    View Item 
    •   Home
    • Events
    • WEP Library ePoster competition 2019
    • View Item
    •   Home
    • Events
    • WEP Library ePoster competition 2019
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguidePlumX LibguideSubmit an Item

    Statistics

    Display statistics

    Genome editing and induced pluripotent stem cells model reveal novel roles of WASP in cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    P31.pdf
    Size:
    21.29Mb
    Format:
    PDF
    Download
    Type
    Poster
    Authors
    Zhou, Xuan
    Suzuki, Keiichiro cc
    J Moresco, James
    Dunn, Sarah
    Xu, Jinna
    Date
    2019-01-13
    Permanent link to this record
    http://hdl.handle.net/10754/655735
    
    Metadata
    Show full item record
    Abstract
    The Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disease that caused by the genetic defect in WAS protein (WASP). The classical syndrome is characterized by thrombocytopenia, immunodeficiency, atopy, autoimmunity, and malignancy, leading to premature death in severe patients. Studies have shown that 13% to 22% of patients develop cancer with the only average onset of 9.5 years; however, the molecular mechanism underlying the early onset and high morbidity of cancer in WAS is still an unsolved issue. As the founding member of actin nucleation-promoting factors, WASP plays a critical role in mediating actin polymerization and remodeling the cytoskeleton. Nevertheless, this function fails to explain malignancy development. Here, by using induced pluripotent stem cells (iPSCs) generated from WAS patient, we found that WAS mutant cells have an abnormal cell cycle. The cell cycle-related genes/pathways are significantly deregulated. We show that WAS deficiency leads to of splicing regulation and epigenetic regulation involved in cell cycle. We confirmed our findings in 4 independent patients with different mutations using macrophages, T, B, and dendritic cells. Interestingly, WASP’s multifaceted function in the nucleus results in synergistic disruption of cell cycle regulation when it is mutated. Taken together, our finding identified a new function of WASP in the cell cycle, which offers a potential target for predicting early cancer in WAS patient as well as a new therapy.
    Conference/Event name
    WEP Library ePoster competition 2019
    Additional Links
    https://epostersonline.com/wep2019/node/162
    Collections
    WEP Library ePoster competition 2019; Posters

    entitlement

     
    DSpace software copyright © 2002-2021  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.