Electrochemical and Scalable Dehydrogenative C(sp 3 )−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow
Type
ArticleKAUST Department
KAUST Catalysis Center (KCC)KAUST Grant Number
URF/1/1974-04-01Date
2019-05-02Online Publication Date
2019-05-02Print Publication Date
2019-05-23Permanent link to this record
http://hdl.handle.net/10754/653109
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Show full item recordAbstract
A hydrogen atom transfer-directed electrochemical intramolecular C−H amination has been developed in which the N-radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.Citation
Nikolaienko P, Jentsch M, Kale AP, Cai Y, Rueping M (2019) Electrochemical and Scalable Dehydrogenative C(sp 3 )−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow. Chemistry – A European Journal 25: 7177–7184. Available: http://dx.doi.org/10.1002/chem.201806092.Sponsors
This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/1974-04-01).Publisher
WileyJournal
Chemistry – A European JournalAdditional Links
https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201806092ae974a485f413a2113503eed53cd6c53
10.1002/chem.201806092