Electrochemical and Scalable Dehydrogenative C(sp 3 )−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow

Type
Article

Authors
Nikolaienko, Pavlo
Jentsch, Marc
Kale, Ajit P.
Cai, Yunfei
Rueping, Magnus

KAUST Department
KAUST Catalysis Center (KCC)

KAUST Grant Number
URF/1/1974-04-01

Online Publication Date
2019-05-02

Print Publication Date
2019-05-23

Date
2019-05-02

Abstract
A hydrogen atom transfer-directed electrochemical intramolecular C−H amination has been developed in which the N-radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.

Citation
Nikolaienko P, Jentsch M, Kale AP, Cai Y, Rueping M (2019) Electrochemical and Scalable Dehydrogenative C(sp 3 )−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow. Chemistry – A European Journal 25: 7177–7184. Available: http://dx.doi.org/10.1002/chem.201806092.

Acknowledgements
This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/1974-04-01).

Publisher
Wiley

Journal
Chemistry – A European Journal

DOI
10.1002/chem.201806092

Additional Links
https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201806092

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