Electrochemical and Scalable Dehydrogenative C(sp 3 )−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow
KAUST DepartmentKAUST Catalysis Center (KCC)
KAUST Grant NumberURF/1/1974-04-01
Online Publication Date2019-05-02
Print Publication Date2019-05-23
Permanent link to this recordhttp://hdl.handle.net/10754/653109
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AbstractA hydrogen atom transfer-directed electrochemical intramolecular C−H amination has been developed in which the N-radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.
CitationNikolaienko P, Jentsch M, Kale AP, Cai Y, Rueping M (2019) Electrochemical and Scalable Dehydrogenative C(sp 3 )−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow. Chemistry – A European Journal 25: 7177–7184. Available: http://dx.doi.org/10.1002/chem.201806092.
SponsorsThis work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/1974-04-01).
JournalChemistry – A European Journal