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dc.contributor.authorShen, Huiting
dc.contributor.authorHan, Jiaojiao
dc.contributor.authorLi, Yanyan
dc.contributor.authorLu, Chenyang
dc.contributor.authorZhou, Jun
dc.contributor.authorLi, Ye
dc.contributor.authorSu, Xiurong
dc.date.accessioned2019-05-21T12:54:37Z
dc.date.available2019-05-21T12:54:37Z
dc.date.issued2019-03-08
dc.identifier.citationShen H, Han J, Li Y, Lu C, Zhou J, et al. (2019) Different host-specific responses in thyroid function and gut microbiota modulation between diet-induced obese and normal mice given the same dose of iodine. Applied Microbiology and Biotechnology 103: 3537–3547. Available: http://dx.doi.org/10.1007/s00253-019-09687-1.
dc.identifier.issn0175-7598
dc.identifier.issn1432-0614
dc.identifier.doi10.1007/s00253-019-09687-1
dc.identifier.urihttp://hdl.handle.net/10754/652944
dc.description.abstractIodine is an important trace element involved in thyroid hormone biosynthesis, while diet-induced obesity is reported to disturb the trace element metabolic balance. Herein, we studied the host-specific responses involved in modulating thyroid function and gut microbiota in obese mice after the iodine treatment and analyzed the possible causes for these responses. Obesity in the mice was induced by a high-fat diet, and the obese and normal mice were treated with the same iodine dosage (18 μg/kg/day) continuously for 8 weeks. Iodine treatment in the obese mice showed a weight-reducing effect, increased the thyroid hormone concentrations, altered the transcriptions of genes involved in thyroid hormone biosynthesis, and modulated the gut microbiota with an increased abundance of pathogenic bacteria and decreased the proportion of beneficial bacteria. However, completely different or even opposite response profiles were observed in the normal hosts. Our work indicated that obesity may exacerbate the risk of thyroid disease with a relatively safe dose of iodine, and individual differences should be considered with trace element supplementation.
dc.description.sponsorshipAcknowledgements: We thank Wiley Editing Service for English language editing. Funding information: This work was sponsored by K.C. Wong Magna Fund in Ningbo University.
dc.publisherSpringer Nature
dc.relation.urlhttps://link.springer.com/article/10.1007%2Fs00253-019-09687-1
dc.subjectObesity
dc.subjectIodine
dc.subjectGut Microbiota
dc.subjectThyroid Dysfunction
dc.titleDifferent host-specific responses in thyroid function and gut microbiota modulation between diet-induced obese and normal mice given the same dose of iodine
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalApplied Microbiology and Biotechnology
dc.contributor.institutionSchool of Marine Science, Ningbo University, 818 Fenghua Road, Ningbo, China.
dc.contributor.institutionDepartment of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, USA
kaust.personLi, Yanyan
dc.date.published-online2019-03-08
dc.date.published-print2019-04


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