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    Activity Assessment of a Halophilic γ-carbonic Anhydrase from the Red Sea Brine Pool Discovery Deep

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    MS Thesis_Vancea_Final.pdf
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    2.698Mb
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    Description:
    MS Thesis
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    Type
    Thesis
    Authors
    Vancea, Alexandra cc
    Advisors
    Rueping, Magnus cc
    Committee members
    Arold, Stefan T. cc
    Al-Babili, Salim cc
    Program
    Bioscience
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2019-04
    Embargo End Date
    2020-05-15
    Permanent link to this record
    http://hdl.handle.net/10754/652899
    
    Metadata
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    Access Restrictions
    At the time of archiving, the student author of this thesis opted to temporarily restrict access to it. The full text of this thesis became available to the public after the expiration of the embargo on 2020-05-15.
    Abstract
    Carbonic anhydrases catalyze a central reaction in life – the inter-conversion between carbon dioxide and water. Consequently, there is an increasing interest in research in using carbonic anhydrases for industrial applications such as biofuel production and carbon capture, since current approaches for CO2 capturing are expensive, harsh and energy demanding. The proof of principle for using carbonic anhydrase in these applications for carbon fixation has been validated. However, the current known and tested carbonic anhydrases are not tolerating the harsh industrial conditions. An ideal carbonic anhydrase should display thermo-, salt, and solvent stability and exhibit a decent reactivity. Herein we present the characterization and activity assessment of a halophilic γ-carbonic anhydrase from the Red Sea brine pool Discovery Deep. Protein X-ray structure exhibited the molecular structure and allowed the successful engineering of a small, active mutant library. Stopped-flow measurements gave insights into the activity and evaluated the engineering principles.
    Citation
    Vancea, A. (2019). Activity Assessment of a Halophilic γ-carbonic Anhydrase from the Red Sea Brine Pool Discovery Deep. KAUST Research Repository. https://doi.org/10.25781/KAUST-E48F5
    DOI
    10.25781/KAUST-E48F5
    ae974a485f413a2113503eed53cd6c53
    10.25781/KAUST-E48F5
    Scopus Count
    Collections
    Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Theses

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