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dc.contributor.authorCooper, Timothy K
dc.contributor.authorSilva, Kathleen A
dc.contributor.authorKennedy, Victoria E
dc.contributor.authorAlghamdi, Sarah
dc.contributor.authorHoehndorf, Robert
dc.contributor.authorSundberg, Beth A
dc.contributor.authorSchofield, Paul N
dc.contributor.authorSundberg, John P
dc.date.accessioned2019-05-09T11:32:31Z
dc.date.available2019-05-09T11:32:31Z
dc.date.issued2019-05-06
dc.identifier.citationCooper TK, Silva KA, Kennedy VE, Alghamdi S, Hoehndorf R, et al. (2019) Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice. Veterinary Pathology: 030098581984482. Available: http://dx.doi.org/10.1177/0300985819844822.
dc.identifier.issn0300-9858
dc.identifier.issn1544-2217
dc.identifier.doi10.1177/0300985819844822
dc.identifier.urihttp://hdl.handle.net/10754/652815
dc.description.abstractDuring a screen for vascular phenotypes in aged laboratory mice, a unique discrete phenotype of hyaline arteriolosclerosis of the intertubular arteries and arterioles of the testes was identified in several inbred strains. Lesions were limited to the testes and did not occur as part of any renal, systemic, or pulmonary arteriopathy or vasculitis phenotype. There was no evidence of systemic or pulmonary hypertension, and lesions did not occur in ovaries of females. Frequency was highest in males of the SM/J (27/30, 90%) and WSB/EiJ (19/26, 73%) strains, aged 383 to 847 days. Lesions were sporadically present in males from several other inbred strains at a much lower (<20%) frequency. The risk of testicular hyaline arteriolosclerosis is at least partially underpinned by a genetic predisposition that is not associated with other vascular lesions (including vasculitis), separating out the etiology of this form and site of arteriolosclerosis from other related conditions that often co-occur in other strains of mice and in humans. Because of their genetic uniformity and controlled dietary and environmental conditions, mice are an excellent model to dissect the pathogenesis of human disease conditions. In this study, a discrete genetically driven phenotype of testicular hyaline arteriolosclerosis in aging mice was identified. These observations open the possibility of identifying the underlying genetic variant(s) associated with the predisposition and therefore allowing future interrogation of the pathogenesis of this condition.
dc.description.sponsorshipNational Cancer Institute[CA034196]
dc.publisherSAGE Publications
dc.relation.urlhttps://journals.sagepub.com/doi/10.1177/0300985819844822
dc.rightsArchived with thanks to Veterinary Pathology
dc.subjectMice
dc.subjectTestis
dc.subjectVascular diseases
dc.subjectarteriosclerosis
dc.subjectArteriolosclerosis
dc.subjectSm/j
dc.subjectWsb/eij
dc.titleHyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice
dc.typeArticle
dc.contributor.departmentBio-Ontology Research Group (BORG)
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer Science Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.identifier.journalVeterinary Pathology
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.
dc.contributor.institutionDepartment of Comparative Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.
dc.contributor.institutionThe Jackson Laboratory, Bar Harbor, ME, USA.
dc.contributor.institutionDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
kaust.personAlghamdi, Sarah
kaust.personHoehndorf, Robert
refterms.dateFOA2020-05-06T00:00:00Z


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