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    Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice

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    Arteriolosclerosis in aging mice Vet Path.pdf
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    Type
    Article
    Authors
    Cooper, Timothy K
    Silva, Kathleen A
    Kennedy, Victoria E
    Alghamdi, Sarah
    Hoehndorf, Robert cc
    Sundberg, Beth A
    Schofield, Paul N
    Sundberg, John P
    KAUST Department
    Bio-Ontology Research Group (BORG)
    Computational Bioscience Research Center (CBRC)
    Computer Science Program
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Date
    2019-05-06
    Permanent link to this record
    http://hdl.handle.net/10754/652815
    
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    Abstract
    During a screen for vascular phenotypes in aged laboratory mice, a unique discrete phenotype of hyaline arteriolosclerosis of the intertubular arteries and arterioles of the testes was identified in several inbred strains. Lesions were limited to the testes and did not occur as part of any renal, systemic, or pulmonary arteriopathy or vasculitis phenotype. There was no evidence of systemic or pulmonary hypertension, and lesions did not occur in ovaries of females. Frequency was highest in males of the SM/J (27/30, 90%) and WSB/EiJ (19/26, 73%) strains, aged 383 to 847 days. Lesions were sporadically present in males from several other inbred strains at a much lower (<20%) frequency. The risk of testicular hyaline arteriolosclerosis is at least partially underpinned by a genetic predisposition that is not associated with other vascular lesions (including vasculitis), separating out the etiology of this form and site of arteriolosclerosis from other related conditions that often co-occur in other strains of mice and in humans. Because of their genetic uniformity and controlled dietary and environmental conditions, mice are an excellent model to dissect the pathogenesis of human disease conditions. In this study, a discrete genetically driven phenotype of testicular hyaline arteriolosclerosis in aging mice was identified. These observations open the possibility of identifying the underlying genetic variant(s) associated with the predisposition and therefore allowing future interrogation of the pathogenesis of this condition.
    Citation
    Cooper TK, Silva KA, Kennedy VE, Alghamdi S, Hoehndorf R, et al. (2019) Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice. Veterinary Pathology: 030098581984482. Available: http://dx.doi.org/10.1177/0300985819844822.
    Sponsors
    National Cancer Institute[CA034196]
    Publisher
    SAGE Publications
    Journal
    Veterinary Pathology
    DOI
    10.1177/0300985819844822
    Additional Links
    https://journals.sagepub.com/doi/10.1177/0300985819844822
    ae974a485f413a2113503eed53cd6c53
    10.1177/0300985819844822
    Scopus Count
    Collections
    Articles; Bio-Ontology Research Group (BORG); Computer Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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