Show simple item record

dc.contributor.advisorHussain, Muhammad Mustafa
dc.contributor.authorBabatain, Wedyan
dc.date.accessioned2019-05-08T05:35:55Z
dc.date.available2021-05-06T00:00:00Z
dc.date.issued2019-05
dc.identifier.citationBabatain, W. (2019). Expandable Polymer Assisted Wearable Personalized Medicinal Platform. KAUST Research Repository. https://doi.org/10.25781/KAUST-S0NC9
dc.identifier.doi10.25781/KAUST-S0NC9
dc.identifier.urihttp://hdl.handle.net/10754/652452
dc.description.abstractConventional healthcare and the practice of medicine largely relies on the ineffective concept of one size fits all. Personalized medicine is an emerging therapeutic approach that aims to develop an advanced therapeutic technique that provides tailor-made therapy based on every individuals’ needs by delivering the right drug at the right time with the right amount of dosage. The advancement in technologies such as flexible electronics, microfluidics, biosensors, and advanced artificial intelligence can enable the realization of a truly effective personalized therapy. However, currently, there is a lack for a personalized minimally-invasive wearable closed-loop drug delivery system that is continuous, automated, conformal to the skin and cost-effective. Thus, this thesis focuses on the design, fabrication, optimization, and application of an automated personalized microfluidics drug delivery platform augmented with flexible biosensors, heaters, and expandable polymeric actuator. The platform provides precise drug delivery with spatiotemporal control over the administered dose as a response to real-time physiological changes of the individual. The system is flexible enough to be conformal to the skin and drug is transdermally administered through biocompatible microneedles. The platform includes a flexible multi-reservoir microfluidics layer, flexible and conformal heating elements, skin sensors and processing units which are powered by a lightweight battery integrated into the platform. The developed platform was fabricated using rapid, cost-effective techniques that are independent of advanced microfabrication facilities to expand its applications to low-resource setting and environments.
dc.language.isoen
dc.subjectPersonalized healthcare
dc.subjectWearable
dc.subjectSensors
dc.subjectActuators
dc.subjectMicrofluidics
dc.titleExpandable Polymer Assisted Wearable Personalized Medicinal Platform
dc.typeThesis
dc.contributor.departmentComputer, Electrical and Mathematical Science and Engineering (CEMSE) Division
dc.rights.embargodate2021-05-06
thesis.degree.grantorKing Abdullah University of Science and Technology
dc.contributor.committeememberAlouini, Mohamed-Slim
dc.contributor.committeememberSchwingenschlögl, Udo
thesis.degree.disciplineElectrical and Computer Engineering
thesis.degree.nameMaster of Science
dc.rights.accessrightsAt the time of archiving, the student author of this thesis opted to temporarily restrict access to it. The full text of this thesis became available to the public after the expiration of the embargo on 2021-05-06.
refterms.dateFOA2019-05-08T05:35:56Z
kaust.request.doiyes


Files in this item

Thumbnail
Name:
Wedyan_MS_Thesis.pdf
Size:
2.860Mb
Format:
PDF
Description:
Final thesis

This item appears in the following Collection(s)

Show simple item record