Magnesium-Catalyzed Hydroboration of Terminal and Internal Alkynes
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Online Publication Date2019-04-12
Print Publication Date2019-05-20
Permanent link to this recordhttp://hdl.handle.net/10754/631875
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AbstractA magnesium-catalyzed hydroboration of alkynes providing good yields and selectivities for a wide range of terminal and symmetrical and unsymmetrical internal alkynes has been developed. The compatibility with many functional groups makes this magnesium catalyzed procedure attractive for late stage functionalization. Experimental mechanistic investigations and DFT calculations reveal insights into the reaction mechanism of the magnesium catalyzed protocol.
CitationMagre M, Maity B, Falconnet A, Cavallo L, Rueping M (2019) Magnesium-Catalyzed Hydroboration of Terminal and Internal Alkynes. Angewandte Chemie International Edition. Available: http://dx.doi.org/10.1002/anie.201902188.
SponsorsB.M. and L.C. acknowledge King Abdullah University of Science and Technology (KAUST) for computational resources of the supercomputer Shaheen II.