Nickel-catalyzed C–N bond activation: activated primary amines as alkylating reagents in reductive cross-coupling
Hock, Katharina J.
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/631810
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AbstractNickel-catalyzed reductive cross coupling of activated primary amines with aryl halides under mild reaction conditions has been achieved for the first time. Due to the avoidance of stoichiometric organometallic reagents and external bases, the scope regarding both coupling partners is broad. Thus, a wide range of substrates, natural products and drugs with diverse functional groups are tolerated. Moreover, experimental mechanistic investigations and density functional theory (DFT) calculations in combination with wavefunction analysis have been performed to understand the catalytic cycle in more detail.
CitationYue H, Zhu C, Shen L, Geng Q, Hock KJ, et al. (2019) Nickel-catalyzed C–N bond activation: activated primary amines as alkylating reagents in reductive cross-coupling. Chemical Science. Available: http://dx.doi.org/10.1039/c9sc00783k.
SponsorsH. Y. acknowledges the China Scholarship Council. C. Z. acknowledges the King Abdullah University of Science and Technology (KAUST) for support and the KAUST Supercomputing Laboratory for providing computational resources of the supercomputer Shaheen II.
PublisherRoyal Society of Chemistry (RSC)
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