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    An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo

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    Name:
    uFIP ECoG manuscript_final_revised.pdf
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    Description:
    Accepted Manuscript
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    Type
    Article
    Authors
    Proctor, Christopher M.
    Uguz, Ilke
    Slezia, Andrea
    Curto, Vincenzo
    Inal, Sahika cc
    Williamson, Adam
    Malliaras, George G.
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2018-11-27
    Online Publication Date
    2018-11-27
    Print Publication Date
    2019-02
    Permanent link to this record
    http://hdl.handle.net/10754/631766
    
    Metadata
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    Abstract
    The challenge of treating neurological disorders has motivated the development of implantable devices that can deliver treatment when and where it is needed. This study presents a novel brain implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.
    Citation
    Proctor CM, Uguz I, Slezia A, Curto V, Inal S, et al. (2018) An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo. Advanced Biosystems 3: 1800270. Available: http://dx.doi.org/10.1002/adbi.201800270.
    Sponsors
    C.M.P. and I.U. contributed equally to this work. The authors thank Dr. Christophe Bernard for providing the facilities for the in vivo experiments. C.M.P. acknowledges funding from a Whitaker International Scholar grant administered by the Institute for International Education. A.W. acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No 716867) as well as Excellence Initiative of Aix-Marseille University—A*MIDEX, a French “Investissements d'Avenir” program.
    Publisher
    Wiley
    Journal
    Advanced Biosystems
    DOI
    10.1002/adbi.201800270
    Additional Links
    https://onlinelibrary.wiley.com/doi/full/10.1002/adbi.201800270
    ae974a485f413a2113503eed53cd6c53
    10.1002/adbi.201800270
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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