An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo
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ArticleAuthors
Proctor, Christopher M.Uguz, Ilke
Slezia, Andrea
Curto, Vincenzo
Inal, Sahika

Williamson, Adam
Malliaras, George G.
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Date
2018-11-27Online Publication Date
2018-11-27Print Publication Date
2019-02Permanent link to this record
http://hdl.handle.net/10754/631766
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The challenge of treating neurological disorders has motivated the development of implantable devices that can deliver treatment when and where it is needed. This study presents a novel brain implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.Citation
Proctor CM, Uguz I, Slezia A, Curto V, Inal S, et al. (2018) An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo. Advanced Biosystems 3: 1800270. Available: http://dx.doi.org/10.1002/adbi.201800270.Sponsors
C.M.P. and I.U. contributed equally to this work. The authors thank Dr. Christophe Bernard for providing the facilities for the in vivo experiments. C.M.P. acknowledges funding from a Whitaker International Scholar grant administered by the Institute for International Education. A.W. acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No 716867) as well as Excellence Initiative of Aix-Marseille University—A*MIDEX, a French “Investissements d'Avenir” program.Publisher
WileyJournal
Advanced BiosystemsAdditional Links
https://onlinelibrary.wiley.com/doi/full/10.1002/adbi.201800270ae974a485f413a2113503eed53cd6c53
10.1002/adbi.201800270