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dc.contributor.authorFan, Wenpei
dc.contributor.authorLu, Nan
dc.contributor.authorShen, Zheyu
dc.contributor.authorTang, Wei
dc.contributor.authorShen, Bo
dc.contributor.authorCui, Zhaowen
dc.contributor.authorShan, Lingling
dc.contributor.authorYang, Zhen
dc.contributor.authorWang, Zhantong
dc.contributor.authorJacobson, Orit
dc.contributor.authorZhou, Zijian
dc.contributor.authorLiu, Yijing
dc.contributor.authorHu, Ping
dc.contributor.authorYang, Weijing
dc.contributor.authorSong, Jibin
dc.contributor.authorZhang, Yang
dc.contributor.authorZhang, Liwen
dc.contributor.authorKhashab, Niveen M.
dc.contributor.authorAronova, Maria A
dc.contributor.authorLu, Guangming
dc.contributor.authorChen, Xiaoyuan
dc.date.accessioned2019-03-27T09:05:29Z
dc.date.available2019-03-27T09:05:29Z
dc.date.issued2019-03-18
dc.identifier.citationFan W, Lu N, Shen Z, Tang W, Shen B, et al. (2019) Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy. Nature Communications 10. Available: http://dx.doi.org/10.1038/s41467-019-09158-1.
dc.identifier.issn2041-1723
dc.identifier.doi10.1038/s41467-019-09158-1
dc.identifier.urihttp://hdl.handle.net/10754/631747
dc.description.abstractThe success of radiotherapy relies on tumor-specific delivery of radiosensitizers to attenuate hypoxia resistance. Here we report an ammonia-assisted hot water etching strategy for the generic synthesis of a library of small-sized (sub-50 nm) hollow mesoporous organosilica nanoparticles (HMONs) with mono, double, triple, and even quadruple framework hybridization of diverse organic moieties by changing only the introduced bissilylated organosilica precursors. The biodegradable thioether-hybridized HMONs are chosen for efficient co-delivery of tert-butyl hydroperoxide (TBHP) and iron pentacarbonyl (Fe(CO)5). Distinct from conventional RT, radiodynamic therapy (RDT) is developed by taking advantage of X-ray-activated peroxy bond cleavage within TBHP to generate •OH, which can further attack Fe(CO)5 to release CO molecules for gas therapy. Detailed in vitro and in vivo studies reveal the X-ray-activated cascaded release of •OH and CO molecules from TBHP/Fe(CO)5 co-loaded PEGylated HMONs without reliance on oxygen, which brings about remarkable destructive effects against both normoxic and hypoxic cancers.
dc.description.sponsorshipWe gratefully acknowledge support from the National Natural Science Foundation of China (51602203, 81530054, 51761145021), the Intramural Research Program (IRP) of the NIBIB, NIH, the Youth Innovation Promotion Association of Chinese Academy of Sciences (2016269), and the National Key Research & Development Program (2016YFC1400600, 2018YFD0800300). We also thank Cindy Clark, NIH Library Writing Center, for manuscript editing assistance.
dc.publisherSpringer Nature
dc.relation.urlhttps://www.nature.com/articles/s41467-019-09158-1
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleGeneric synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentChemical Science Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalNature Communications
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
dc.contributor.institutionDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China.
dc.contributor.institutionDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, 310000, Hangzhou, Zhejiang, China.
dc.contributor.institutionInstitute of Radiation Medicine, Fudan University, 200032, Shanghai, China.
dc.contributor.institutionState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050, Shanghai, China.
dc.contributor.institutionLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892, USA.
kaust.personZhang, Yang
kaust.personZhang, Liwen
kaust.personKhashab, Niveen M.
refterms.dateFOA2019-03-27T13:38:27Z
dc.date.published-online2019-03-18
dc.date.published-print2019-12


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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.