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dc.contributor.authorCali, Corrado
dc.contributor.authorTauffenberger, Arnaud
dc.contributor.authorMagistretti, Pierre J.
dc.date.accessioned2019-03-11T07:16:40Z
dc.date.available2019-03-11T07:16:40Z
dc.date.issued2019-03-06
dc.identifier.citationCalì C, Tauffenberger A, Magistretti P (2019) The Strategic Location of Glycogen and Lactate: From Body Energy Reserve to Brain Plasticity. Frontiers in Cellular Neuroscience 13. Available: http://dx.doi.org/10.3389/fncel.2019.00082.
dc.identifier.issn1662-5102
dc.identifier.doi10.3389/fncel.2019.00082
dc.identifier.urihttp://hdl.handle.net/10754/631540
dc.description.abstractBrain energy metabolism has been the object of intense research in recent years. Pioneering work has identified the different cell types involved in energy production and use. Recent evidence has demonstrated a key role of L-Lactate in brain energy metabolism, producing a paradigm-shift in our understanding of the neuronal energy metabolism. At the center of this shift, is the identification of a central role of astrocytes in neuroenergetics. Thanks to their morphological characteristics, they are poised to take up glucose from the circulation and deliver energy substrates to neurons. Astrocyte neuron lactate shuttle (ANLS) model, has shown that the main energy substrate that astrocytes deliver to neurons is L-Lactate, to sustain neuronal oxidative metabolism. L-Lactate can also be produced from glycogen, the storage form of glucose, which is exclusively localized in astrocytes. Inhibition of glycogen metabolism and the ensuing inhibition of L-Lactate production leads to cognitive dysfunction. Experimental evidence indicates that the role of lactate in cognitive function relates not only to its role as a metabolic substrate for neurons but also as a signaling molecule for synaptic plasticity. Interestingly, a similar metabolic uncoupling appears to exist in peripheral tissues plasma, whereby glucose provides L-Lactate as the substrate for cellular oxidative metabolism. In this perspective article, we review the known information on the distribution of glycogen and lactate within brain cells, and how this distribution relates to the energy regime of glial vs. neuronal cells.
dc.description.sponsorshipThis work was supported by the CRG Grant No. 2313 from Global Collaborative Research, King Abdullah University of Science and Technology “KAUST-EPFL Alliance for Integrative Modeling of Brain Energy Metabolism.”
dc.publisherFrontiers Media SA
dc.relation.urlhttps://www.frontiersin.org/articles/10.3389/fncel.2019.00082/full
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleThe Strategic Location of Glycogen and Lactate: From Body Energy Reserve to Brain Plasticity
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalFrontiers in Cellular Neuroscience
dc.eprint.versionPublisher's Version/PDF
kaust.personCali, Corrado
kaust.personTauffenberger, Arnaud
kaust.personMagistretti, Pierre J.
kaust.grant.number2313
refterms.dateFOA2019-03-13T08:16:52Z


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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.