Cobalt ferrite supported on reduced graphene oxide as a T2 contrast agent for magnetic resonance imaging
Batra, Nitin M
Alyami, Mram Z.
Khashab, Niveen M.
Da Costa, Pedro M. F. J.
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Chemical Science Program
Material Science and Engineering Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Thin Films & Characterization
Permanent link to this recordhttp://hdl.handle.net/10754/631507
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AbstractNanoscaled spinel-structured ferrites bear promise as next-generation contrast agents for magnetic resonance imaging. However, the small size of the particles commonly leads to colloidal instability under physiological conditions. To circumvent this problem, supports onto which the dispersed nanoparticles can be anchored have been proposed. Amongst these, flakes of graphene have shown interesting performance but it remains unknown if and how their surface texture and chemistry affect the magnetic properties and relaxation time (T2) of the ferrite nanoparticles. Here, it is shown that the type of graphene oxide (GO) precursor, used to make composites of cobalt ferrite (CoFe2O4) and reduced GO, influences greatly not just the T2 but also the average size, dispersion and magnetic behaviour of the grafted nanoparticles. Accordingly, and without compromising biocompatibility, a judicious choice of the initial GO precursor can result in the doubling of the proton relaxivity rate in this system.
CitationAlazmi A, Singaravelu V, Batra NM, Smajic J, Alyami M, et al. (2019) Cobalt ferrite supported on reduced graphene oxide as a T2 contrast agent for magnetic resonance imaging. RSC Advances 9: 6299–6309. Available: http://dx.doi.org/10.1039/c8ra09476d.
SponsorsWe are thankful for the financial support from KAUST (BAS/1/1346-01-01 and URF/1/3001-01-01). The technical support from the Core Labs at KAUST is appreciated. The TOC figure was created by Heno Hwang, scientific illustrator at KAUST.
PublisherRoyal Society of Chemistry (RSC)
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