Customized mesoporous metal organic frameworks engender stable enzymatic nanoreactors
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Chemical Science Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Permanent link to this recordhttp://hdl.handle.net/10754/631225
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AbstractHere, the porosity of a metal organic framework (MIL-101) is tailored by the choice of the solvent occupying the pores in a template free acid etching process. Employing a slightly basic solvent such as DMF afforded big pores around 30 nm (BP-MIL-101). Catalase (CAT), which is a large protein (6 × 10 nm), was successfully encapsulated by a diffusion-based method with a high capacity of 12.5%. BP-MIL-101 could successfully protect CAT from both digestion and denaturation while maintaining its catalytic activity. This paves the way for encapsulating different large biological targets for eventual translation and delivery.
CitationZhang L, Baslyman W, Yang P, Khashab NM (2019) Customized mesoporous metal organic frameworks engender stable enzymatic nanoreactors. Chemical Communications 55: 620–623. Available: http://dx.doi.org/10.1039/c8cc08790c.
PublisherRoyal Society of Chemistry (RSC)