AuthorsColuccio, Maria Laura
Raj, Pushparani Michael
Di Fabrizio, Enzo M.
KAUST DepartmentMaterial Science and Engineering Program
Physical Science and Engineering (PSE) Division
Online Publication Date2019-01-28
Print Publication Date2019-03
Permanent link to this recordhttp://hdl.handle.net/10754/631136
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AbstractThis review covers several aspects of microfluidic devices used for culturing and monitoring of both adherent and non-adherent cells, including a multitude of applications. A comparison of available platforms with high throughput analysis, automation capability, interface to sensors and integration, is reported. Aspects, such as operational versatility of the devices, are scrutinized in terms of their analytical efficacy. It is found that due to multi-functionality capability of modern microfluidics, there is big amount of experimental data obtainable from a single device, allowing complex experimental control and efficient data correlation, particularly important when biomedical studies are considered. Hence several examples on cell culture and monitoring are given in this review, including details on design of microfluidic devices with their distinctive technological peculiarities.
CitationColuccio ML, Perozziello G, Malara N, Parrotta E, Zhang P, et al. (2019) Microfluidic platforms for cell cultures and investigations. Microelectronic Engineering 208: 14–28. Available: http://dx.doi.org/10.1016/j.mee.2019.01.004.
SponsorsThis work was supported by the project for Young researchers financed from the Italian Ministry of Health “High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices” (CUP J65C13001350001, project No. GR-2010-2311677) granted to the nanotechnology laboratory of the Department of Experimental and Clinical Medicine of the University “Magna Graecia” of Catanzaro.