Sustainable Manganese-Catalyzed Solvent-Free Synthesis of Pyrroles from 1,4-Diols and Primary Amines
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Online Publication Date2018-12-24
Print Publication Date2019-01-04
Permanent link to this recordhttp://hdl.handle.net/10754/630913
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AbstractA general and selective metal-catalyzed conversion of biomass-derived primary diols and amines to the highly valuable 2,5-unsubstituted pyrroles has been developed. The reaction is catalyzed by a stable nonprecious manganese complex (1 mol %) in the absence of organic solvents whereby water and molecular hydrogen are the only side products. The manganese catalyst shows unprecedented selectivity, avoiding the formation of pyrrolidines, cyclic imides, and lactones.
CitationBorghs JC, Lebedev Y, Rueping M, El-Sepelgy O (2018) Sustainable Manganese-Catalyzed Solvent-Free Synthesis of Pyrroles from 1,4-Diols and Primary Amines. Organic Letters 21: 70–74. Available: http://dx.doi.org/10.1021/acs.orglett.8b03506.
SponsorsJ.C.B. is thankful for financial support of the German Federal Environmental Foundation (DBU).
PublisherAmerican Chemical Society (ACS)
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