Genetically encoded biotin and biotin-analogs and use thereof

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Patent
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Type
Patent
Patent Status
Published Application
Authors
Hohl, Adrian
Eppinger, Jörg cc
Assignee
King Abdullah University Of Science And Technology
KAUST Department
Biological & Organometallic Catalysis Laboratories
Biological and Environmental Sciences and Engineering (BESE) Division
Bioscience Program
Chemical Science Program
KAUST Catalysis Center (KCC)
Office of the VP
Physical Science and Engineering (PSE) Division
Date
2018-11-15
Submitted Date
2018-05-07
Permanent link to this record
http://hdl.handle.net/10754/630906

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Abstract
Embodiments of the present disclosure describe non-canonical amino acids characterized by the formula A—L—B, where A is an amino acid, L is a linker, and B is a biotin or a biotin-analog group. Embodiments describe translation systems comprising an orthogonal tRNA; an orthogonal aminoacyl-tRNA-synthetase, and a non- canonical amino acid with a biotin-containing side-chain or biotin-analog-containing side-chain; wherein the O-RS preferentially aminoacylates the O-tRNA with the non- canonical amino acid; wherein the non-canonical amino acid is incorporated into a protein at a specific site during translation
Application Number
WO2018207077A1
Additional Links
https://patents.google.com/patent/WO2018207077A1/fr
Collections
Biological and Environmental Sciences and Engineering (BESE) Division; Patents; Bioscience Program; Physical Science and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC)