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    Genetically encoded biotin and biotin-analogs and use thereof

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    Name:
    WO2018207077A1.pdf
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    945.8Kb
    Format:
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    Description:
    Patent
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    Type
    Patent
    Patent Status
    Published Application
    Authors
    Hohl, Adrian
    Eppinger, Jörg cc
    Assignee
    King Abdullah University Of Science And Technology
    KAUST Department
    Biological & Organometallic Catalysis Laboratories
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Chemical Science Program
    KAUST Catalysis Center (KCC)
    Office of the VP
    Physical Science and Engineering (PSE) Division
    Date
    2018-11-15
    Submitted Date
    2018-05-07
    Permanent link to this record
    http://hdl.handle.net/10754/630906
    
    Metadata
    Show full item record
    Abstract
    Embodiments of the present disclosure describe non-canonical amino acids characterized by the formula A—L—B, where A is an amino acid, L is a linker, and B is a biotin or a biotin-analog group. Embodiments describe translation systems comprising an orthogonal tRNA; an orthogonal aminoacyl-tRNA-synthetase, and a non- canonical amino acid with a biotin-containing side-chain or biotin-analog-containing side-chain; wherein the O-RS preferentially aminoacylates the O-tRNA with the non- canonical amino acid; wherein the non-canonical amino acid is incorporated into a protein at a specific site during translation
    Application Number
    WO2018207077A1
    Additional Links
    https://patents.google.com/patent/WO2018207077A1/fr
    Collections
    Biological and Environmental Sciences and Engineering (BESE) Division; Patents; Bioscience Program; Physical Science and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC)

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