3D-Printed Cross-Flow Mixer Gradient within Minutes for Microfluidic Applications
Khashab, Niveen M.
Salama, Khaled N.
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Biological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Online Publication Date2018-12-24
Print Publication Date2018-10
Permanent link to this recordhttp://hdl.handle.net/10754/630892
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AbstractThis paper reports on a compact new cross-flow 3D mixer that is integrated with a gradient generator into one device for toxicology applications. The device has two parts: the first mixes two solvents while the second generates gradients of the obtained solutions. The outlet of the 3D cross-flow mixer is integrated with a linear channel that aids in achieving this gradient by changing flow rates. The dye-visualization test confirm the functionality of mixer and gradient. The mesh structure of the mixer provided excellent mixing regime and is confirmed by experimental and simulation results. The compact size (25 Ã— 25 Ã— 3 mm) and the reduced cost ($1.5) of the device enable the device to be disposable. We aim to study doxorubicin drug at different concentration generated by the device to culture human embryonic kidney (HEK) from the 293-cell line enabling the devices to be used for cellular studies. The carefully designed geometry of the device finds applications in drug toxicology testing devices, micro-total analysis systems ( µ- TAs),and other lab-on-chip devices.
CitationSivashankar S, Mkaouar H, Mashraei Y, Alamoudi K, Khashab NM, et al. (2018) 3D-Printed Cross-Flow Mixer Gradient within Minutes for Microfluidic Applications. 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS). Available: http://dx.doi.org/10.1109/biocas.2018.8584743.