Direct Cross-Coupling of Allylic C(sp3 )−H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Online Publication Date2018-07-16
Print Publication Date2018-08-06
Permanent link to this recordhttp://hdl.handle.net/10754/630759
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AbstractAn efficient protocol for the direct allylic C(sp3)−H bond activation of unactivated tri- and tetrasubstituted alkenes and their functionalization with aryl- and vinylbromides by nickel and visible-light photocatalysis has been developed. The method allows C(sp2)−C(sp3) formation under mild reaction conditions with good functional-group tolerance and excellent regioselectivity.
CitationHuang L, Rueping M (2018) Direct Cross-Coupling of Allylic C(sp3 )−H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis. Angewandte Chemie International Edition 57: 10333–10337. Available: http://dx.doi.org/10.1002/anie.201805118.
SponsorsThe research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ ERC Grant Agreement no. 617044 (SunCatChem).