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    Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury

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    Type
    Article
    Authors
    Carteron, Laurent
    Solari, Daria
    Patet, Camille
    Quintard, Hervé
    Miroz, John-Paul
    Bloch, Jocelyne
    Daniel, Roy T.
    Hirt, Lorenz
    Eckert, Philippe
    Magistretti, Pierre J. cc
    Oddo, Mauro
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2018-06-20
    Online Publication Date
    2018-06-20
    Print Publication Date
    2018-10
    Permanent link to this record
    http://hdl.handle.net/10754/630465
    
    Metadata
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    Abstract
    Lactate promotes cerebral blood flow and is an efficient substrate for the brain, particularly at times of glucose shortage. Hypertonic lactate is neuroprotective after experimental brain injury; however, human data are limited.Prospective study (clinicaltrials.gov NCT01573507).Academic ICU.Twenty-three brain-injured subjects (13 traumatic brain injury/10 subarachnoid hemorrhage; median age, 59 yr [41-65 yr]; median Glasgow Coma Scale, 6 [3-7]).Three-hour IV infusion of hypertonic lactate (sodium lactate, 1,000 mmol/L; concentration, 30 µmol/kg/min) administered 39 hours (26-49 hr) from injury.We examined the effect of hypertonic lactate on cerebral perfusion (using transcranial Doppler) and brain energy metabolism (using cerebral microdialysis). The majority of subjects (13/23 = 57%) had reduced brain glucose availability (baseline pretreatment cerebral microdialysis glucose, < 1 mmol/L) despite normal baseline intracranial pressure (10 [7-15] mm Hg). Hypertonic lactate was associated with increased cerebral microdialysis lactate (+55% [31-80%]) that was paralleled by an increase in middle cerebral artery mean cerebral blood flow velocities (+36% [21-66%]) and a decrease in pulsatility index (-21% [13-26%]; all p < 0.001). Cerebral microdialysis glucose increased above normal range during hypertonic lactate (+42% [30-78%]; p < 0.05); reduced brain glucose availability correlated with a greater improvement of cerebral microdialysis glucose (Spearman r = -0.53; p = 0.009). No significant changes in cerebral perfusion pressure, mean arterial pressure, systemic carbon dioxide, and blood glucose were observed during hypertonic lactate (all p > 0.1).This is the first clinical demonstration that hypertonic lactate resuscitation improves both cerebral perfusion and brain glucose availability after brain injury. These cerebral vascular and metabolic effects appeared related to brain lactate supplementation rather than to systemic effects.
    Citation
    Carteron L, Solari D, Patet C, Quintard H, Miroz J-P, et al. (2018) Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury*. Critical Care Medicine 46: 1649–1655. Available: http://dx.doi.org/10.1097/ccm.0000000000003274.
    Publisher
    Ovid Technologies (Wolters Kluwer Health)
    Journal
    Critical Care Medicine
    DOI
    10.1097/ccm.0000000000003274
    Additional Links
    https://insights.ovid.com/crossref?an=00003246-900000000-96236
    ae974a485f413a2113503eed53cd6c53
    10.1097/ccm.0000000000003274
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program

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