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Sustainable Alkylation of Unactivated Esters and Amides with Alcohols Enabled by Manganese Catalysis

dc.contributor.authorJang, Yoon Kyung
dc.contributor.authorKrückel, Tobias
dc.contributor.authorRueping, Magnus
dc.contributor.authorEl-Sepelgy, Osama
dc.date.accessioned2018-12-12T06:33:22Z
dc.date.available2018-12-12T06:33:22Z
dc.date.issued2018-12-03
dc.identifier.citationJang YK, Krückel T, Rueping M, El-Sepelgy O (2018) Sustainable Alkylation of Unactivated Esters and Amides with Alcohols Enabled by Manganese Catalysis. Organic Letters. Available: http://dx.doi.org/10.1021/acs.orglett.8b03184.
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.doi10.1021/acs.orglett.8b03184
dc.identifier.urihttp://hdl.handle.net/10754/630271
dc.description.abstractThe first example of manganese-catalyzed C-alkylation of the carboxylic acid derivatives is reported. The bench-stable homogeneous manganese complex enables the transformation of the renewable alcohol and carboxylic acid derivative feedstock to higher value esters and amides. The reaction operates via hydrogen autotransfer and ideally produces water as the only side product. Importantly, aliphatic-, benzylic-, and heterocyclic-containing alcohols can be used as alkylating reagents, eliminating the need for mutagenic alkyl halides.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/acs.orglett.8b03184
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.orglett.8b03184.
dc.titleSustainable Alkylation of Unactivated Esters and Amides with Alcohols Enabled by Manganese Catalysis
dc.typeArticle
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalOrganic Letters
dc.eprint.versionPost-print
dc.contributor.institutionInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
kaust.personRueping, Magnus
refterms.dateFOA2018-12-12T06:40:34Z
dc.date.published-online2018-12-03
dc.date.published-print2018-12-21


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