Sustainable Alkylation of Unactivated Esters and Amides with Alcohols Enabled by Manganese Catalysis
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Online Publication Date2018-12-03
Print Publication Date2018-12-21
Permanent link to this recordhttp://hdl.handle.net/10754/630271
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AbstractThe first example of manganese-catalyzed C-alkylation of the carboxylic acid derivatives is reported. The bench-stable homogeneous manganese complex enables the transformation of the renewable alcohol and carboxylic acid derivative feedstock to higher value esters and amides. The reaction operates via hydrogen autotransfer and ideally produces water as the only side product. Importantly, aliphatic-, benzylic-, and heterocyclic-containing alcohols can be used as alkylating reagents, eliminating the need for mutagenic alkyl halides.
CitationJang YK, Krückel T, Rueping M, El-Sepelgy O (2018) Sustainable Alkylation of Unactivated Esters and Amides with Alcohols Enabled by Manganese Catalysis. Organic Letters. Available: http://dx.doi.org/10.1021/acs.orglett.8b03184.
PublisherAmerican Chemical Society (ACS)