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    TGF-b2, catalase activity, H2O2 output and metastatic potential of diverse types of tumour

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    467191.full.pdf
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    Description:
    Preprint
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    Type
    Preprint
    Authors
    Haidar, Malak
    Metheni, Mehdi
    Batteux, Frederic
    Langsley, Gordon
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Computational Bioscience Research Center (CBRC)
    Pathogen Genomics Laboratory
    Date
    2018-11-14
    Permanent link to this record
    http://hdl.handle.net/10754/629953
    
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    Abstract
    Theileria annulata is a protozoan parasite that infects and transforms bovine macrophages causing a myeloid-leukaemia-like disease called tropical theileriosis. TGF-b2 is highly expressed in many cancer cells and is significantly increased in Theileria-transformed macrophages, as are levels of Reactive Oxygen Species (ROS), notably H2O2. Here, we describe the interplay between TGF-b2 and ROS in cellular transformation. We show that TGF-b2 drives expression of catalase to reduce the amount of H2O2 produced by T. annulata-transformed bovine macrophages, as well as by human lung (A549) and colon cancer (HT-29) cell lines. Theileria-transformed macrophages attenuated for dissemination express less catalase and produce more H2O2, but regain both virulent migratory and matrigel traversal phenotypes when stimulated with TGF-b2, or catalase that reduce H2O2 output. Increased H2O2 output therefore, underpins the aggressive dissemination phenotype of diverse tumour cell types, but in contrast, too much H2O2 can dampen dissemination.
    Citation
    Haidar M, Metheni M, Batteux F, Langsley G (2018) TGF-b2, catalase activity, H2O2 output and metastatic potential of diverse types of tumour. Available: http://dx.doi.org/10.1101/467191.
    Sponsors
    We thank Arnab Pain for fruitful discussion and input when writing the manuscript. MH was supported by a PhD CNR fellowship from the Lebanese government. GL acknowledges support from ANR grant (11 BSV3 01602), Labex ParaFrap (ANR-11-LABX-0024) and core support from INSERM and the CNRS.
    Publisher
    Cold Spring Harbor Laboratory
    DOI
    10.1101/467191
    10.1016/j.freeradbiomed.2019.01.010
    Additional Links
    https://www.biorxiv.org/content/early/2018/11/14/467191
    ae974a485f413a2113503eed53cd6c53
    10.1101/467191
    Scopus Count
    Collections
    Biological and Environmental Science and Engineering (BESE) Division; Preprints; Computational Bioscience Research Center (CBRC)

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