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    An Arabidopsis thaliana leucine-rich repeat protein harbors an adenylyl cyclase catalytic center and affects responses to pathogens

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    Type
    Article
    Authors
    Bianchet, Chantal
    Wong, Aloysius Tze cc
    Quaglia, Mara cc
    Alquraishi, May Majed
    Gehring, Christoph A cc
    Ntoukakis, Vardis
    Pasqualini, Stefania
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Chemical Engineering Program
    Molecular Signalling Group
    Physical Science and Engineering (PSE) Division
    Date
    2018-11-03
    Online Publication Date
    2018-11-03
    Print Publication Date
    2019-01
    Permanent link to this record
    http://hdl.handle.net/10754/629936
    
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    Abstract
    Adenylyl cyclases (ACs) catalyze the formation of the second messenger cAMP from ATP. Here we report the characterization of an Arabidopsis thaliana leucine-rich repeat (LRR) protein (At3g14460; AtLRRAC1) as an adenylyl cyclase. Using an AC-specific search motif supported by computational assessments of protein models we identify an AC catalytic center within the N-terminus and demonstrate that AtLRRAC1 can generate cAMP in vitro. Knock-out mutants of AtLRRAC1 have compromised immune responses to the biotrophic fungus Golovinomyces orontii and the hemibiotrophic bacteria Pseudomonas syringae, but not against the necrotrophic fungus Botrytis cinerea. These findings are consistent with a role of cAMP-dependent pathways in the defense against biotrophic and hemibiotrophic plant pathogens.
    Citation
    Bianchet C, Wong A, Quaglia M, Alqurashi M, Gehring C, et al. (2018) An Arabidopsis thaliana leucine-rich repeat protein harbors an adenylyl cyclase catalytic center and affects responses to pathogens. Journal of Plant Physiology. Available: http://dx.doi.org/10.1016/j.jplph.2018.10.025.
    Sponsors
    This project was funded by King Abdullah University of Science and Technology, Royal Society, Biotechnology and Biological Science Research Council grants (BB/L019345/1 and BB/M017982/1) and “Fondo di Ateneo per la Ricerca di Base 2015” financed by University of Perugia. We are grateful to Aleš Lebeda and Božena Sedláková (Palacký University, Olomouc) for providing the Golovinomyces orontii isolates. AW is supported by grants from the National Natural Science Foundation of China (31850410470) and the Zhejiang Provincial Natural Science Foundation of China (Q19C130001).
    Publisher
    Elsevier BV
    Journal
    Journal of Plant Physiology
    DOI
    10.1016/j.jplph.2018.10.025
    Additional Links
    https://www.sciencedirect.com/science/article/pii/S0176161718305650
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jplph.2018.10.025
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Physical Science and Engineering (PSE) Division; Chemical Engineering Program

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