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dc.contributor.authorMerzaban, Jasmeen
dc.contributor.authorAbu Samra, Dina Bashir Kamil
dc.contributor.authorAl-Amoodi, Asma S.
dc.date.accessioned2018-11-12T07:59:50Z
dc.date.available2018-11-12T07:59:50Z
dc.date.issued2018-09-27
dc.date.submitted2018-03-02
dc.identifier.urihttp://hdl.handle.net/10754/629849
dc.description.abstractIt has been discovered that CD34 neg cells, for example HSPCs, can be modified to increase their ability to migrate and to engraft in bone marrow. One embodiment provides a method for modifying CD34 neg cells by using glycosyltransferase-programmed stereosubstitution (GPS) to create relevant selectin-binding glycan determinants on the cell surface. For example, the CD34 neg cells can be treated with a fucosyltransferase, such as an α(1,3)-linkage-specific fucosyltransferase. Representative enzymes that can be used include, but are not limited to fucosyltransferase VI (FTVI or FucT-6) or fucosyltransferase VII (FTVII of FucT-7). These enzymes specifically places a fucose onto a terminal type 2-lactosamine unit; if that lactosamine is capped with an α(2,3)-linked sialic acid, sLe x is created.
dc.relation.urlhttps://patents.google.com/patent/WO2018172869A1/en
dc.titleCompositions and methods for preparing cd34neg stem cells for transplant
dc.typePatent
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentChemical and Biological Engineering Program
dc.description.statusPublished Application
kaust.personMerzaban, Jasmeen S.
kaust.personAbu Samra, Dina Bashir Kamil
kaust.personAl-Amoodi, Asma
dc.contributor.assigneeKing Abdullah University Of Science And Technology
dc.identifier.applicationnumberWO2018172869A1
refterms.dateFOA2018-11-12T07:59:57Z


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