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    Compositions and methods for preparing cd34neg stem cells for transplant

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    Name:
    WO2018172869A1.pdf
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    1.507Mb
    Format:
    PDF
    Description:
    Patent
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    Type
    Patent
    Patent Status
    Published Application
    Authors
    Merzaban, Jasmeen cc
    Abu Samra, Dina Bashir Kamil cc
    Al-Amoodi, Asma S. cc
    Assignee
    King Abdullah University Of Science And Technology
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Chemical and Biological Engineering Program
    Date
    2018-09-27
    Submitted Date
    2018-03-02
    Permanent link to this record
    http://hdl.handle.net/10754/629849
    
    Metadata
    Show full item record
    Abstract
    It has been discovered that CD34 neg cells, for example HSPCs, can be modified to increase their ability to migrate and to engraft in bone marrow. One embodiment provides a method for modifying CD34 neg cells by using glycosyltransferase-programmed stereosubstitution (GPS) to create relevant selectin-binding glycan determinants on the cell surface. For example, the CD34 neg cells can be treated with a fucosyltransferase, such as an α(1,3)-linkage-specific fucosyltransferase. Representative enzymes that can be used include, but are not limited to fucosyltransferase VI (FTVI or FucT-6) or fucosyltransferase VII (FTVII of FucT-7). These enzymes specifically places a fucose onto a terminal type 2-lactosamine unit; if that lactosamine is capped with an α(2,3)-linked sialic acid, sLe x is created.
    Application Number
    WO2018172869A1
    Additional Links
    https://patents.google.com/patent/WO2018172869A1/en
    Collections
    Biological and Environmental Science and Engineering (BESE) Division; Patents; Bioscience Program; Chemical Engineering Program

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