Heterogeneous Visible-Light Photoredox Catalysis with Graphitic Carbon Nitride for α-Aminoalkyl Radical Additions, Allylations, and Heteroarylations
KAUST DepartmentKAUST Catalysis Center (KCC)
Online Publication Date2018-09-17
Print Publication Date2018-10-05
Permanent link to this recordhttp://hdl.handle.net/10754/628813
MetadataShow full item record
AbstractA protocol for the photooxidative activation of α-silylamines and α-amino acids for desilylative and decarboxylative additions, allylations, and heteroarylations in the presence of graphitic carbon nitride (g-C3N4) was developed. The procedure has broad scope and provides the desired products in high yields. The heterogeneous nature of the g-C3N4 catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The photoredox catalyzed reactions can also be conducted in continuous photo flow fashion and scaled up to gram-scale. Thus, the stable and readily available polymeric g-C3N4 provides an alternative to homogeneous photosensitizers for the generation of valuable radical intermediates for applications in synthesis and catalysis.
CitationCai Y, Tang Y, Fan L, Lefebvre Q, Hou H, et al. (2018) Heterogeneous Visible-Light Photoredox Catalysis with Graphitic Carbon Nitride for α-Aminoalkyl Radical Additions, Allylations, and Heteroarylations. ACS Catalysis: 9471–9476. Available: http://dx.doi.org/10.1021/acscatal.8b02937.
SponsorsY.C. gratefully acknowledges the Alexander von Humboldt foundation for a fellowship. The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement no. 617044 (SunCatChem).
PublisherAmerican Chemical Society (ACS)