Brønsted Base Assisted Photoredox Catalysis: Proton Coupled Electron Transfer for Remote C−C Bond Formation via Amidyl Radicals
KAUST DepartmentKAUST Catalysis Center (KCC)
Online Publication Date2018-08-27
Print Publication Date2018-09-20
Permanent link to this recordhttp://hdl.handle.net/10754/628808
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AbstractThe synthesis of alkyne- and alkene-decorated lactams has been achieved through a photoredox-initiated radical cascade reaction. The developed Brønsted base assisted, photoredox-catalyzed, intramolecular 5-exo-trig cyclization/intermolecular radical addition/elimination reaction provides facile access to functionalized γ-lactams, with good functional group tolerance and high yields.
CitationJia J, Ho YA, Bülow RF, Rueping M (2018) Brønsted Base Assisted Photoredox Catalysis: Proton Coupled Electron Transfer for Remote C−C Bond Formation via Amidyl Radicals. Chemistry - A European Journal 24: 14054–14058. Available: http://dx.doi.org/10.1002/chem.201802907.
SponsorsY.A.H. would like to thank Deutscher Akademischer Austauschdienst (DAAD) for a doctoral scholarship. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement no. 617044 (SunCatChem).
JournalChemistry - A European Journal