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dc.contributor.authorFrøkjær-Jensen, Christian
dc.date.accessioned2018-09-26T13:27:36Z
dc.date.available2018-09-26T13:27:36Z
dc.date.issued2018-09-16
dc.identifier.citationFrøkjær-Jensen C (2018) A balance between silencing foreign DNA and protecting self in Caenorhabditis elegans. Current Opinion in Systems Biology. Available: http://dx.doi.org/10.1016/j.coisb.2018.09.007.
dc.identifier.issn2452-3100
dc.identifier.doi10.1016/j.coisb.2018.09.007
dc.identifier.urihttp://hdl.handle.net/10754/628762
dc.description.abstractUnrestrained transposon mobilization threatens genome integrity. To survive, organisms have evolved silencing pathways capable of distinguishing self from non-self. This review emphasizes C. elegans genome defense with a particular emphasis on systems-level detection of foreign DNA and the balance between silencing and protective pathways. Abundant small RNAs (piRNAs and siRNAs), aberrant DNA structures (e.g., introns), and heterochromatin domains largely mediate silencing. For example, CRISPR-based manipulation of endogenous piRNAs has elucidated precise targeting rules and a novel, conserved role in tuning endogenous germline gene expression. Protective pathways are only just becoming clear: small RNA pathways (CSR-1), deamination of endogenous dsRNA, and a pervasive, embedded DNA watermark (PATCs) can all counteract silencing to protect endogenous genes.
dc.description.sponsorshipI would like to thank Darryl Conte, Carolyn Phillips, and an anonymous reviewer for helpful suggestions on the manuscript. Funding: This work was supported by KAUST's internal research support.
dc.publisherElsevier BV
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S2452310018300854
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Current Opinion in Systems Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Current Opinion in Systems Biology, [, , (2018-09-16)] DOI: 10.1016/j.coisb.2018.09.007 . © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleA balance between silencing foreign DNA and protecting self in Caenorhabditis elegans
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalCurrent Opinion in Systems Biology
dc.eprint.versionPost-print
kaust.personFroekjaer Jensen, Christian
refterms.dateFOA2018-09-27T08:26:47Z
dc.date.published-online2018-09-16
dc.date.published-print2019-02


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