Biofunctionalized Two-Dimensional Ti3C2 MXenes for Ultrasensitive Detection of Cancer Biomarker
KAUST DepartmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Material Science and Engineering Program
Physical Science and Engineering (PSE) Division
Online Publication Date2018-08-31
Print Publication Date2018-12
Permanent link to this recordhttp://hdl.handle.net/10754/628698
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AbstractIn this work, ultrathin Ti3C2-MXene nanosheets were synthesized by minimally intensive layer delamination methods, and uniformly functionalized with aminosilane (f-Ti3C2-MXene) to provide a covalent binding for the immobilized bio-receptor (anti-CEA) for label free, ultrasensitive detection of cancer biomarker (carcinoembryonic antigen, CEA). The effect of different redox probes on the electrochemical behavior of f-Ti3C2-MXene was investigated and found that hexaammineruthenium ([Ru(NH3)6]3+) is the preferable redox probe for biosensing. The fabricated biofunctionalized Ti3C2-MXene exhibits a linear detection range of 0.0001–2000 ngmL−1 with sensitivity of 37.9 µAng−1mLcm−2 per decade. The wider linear detection range of our f-Ti3C2-MXene is not only higher than previously reported pristine 2D nanomaterials, but is even comparable to other hybrid 2D nanomaterials. We believe that this work opens a new window for development of MXene-based highly sensitive DNA, aptamer, enzyme, antibody, and cell based biosensors, and could be further used in drug delivery application.
CitationKumar S, Lei Y, Alshareef NH, Quevedo-Lopez MA, Salama KN (2018) Biofunctionalized Two-Dimensional Ti3C2 MXenes for Ultrasensitive Detection of Cancer Biomarker. Biosensors and Bioelectronics. Available: http://dx.doi.org/10.1016/j.bios.2018.08.076.
SponsorsWe thank Prof. Sahika Inal for providing the serum sample. Research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST).
JournalBiosensors and Bioelectronics