Genome sequence analysis of Zooshikella ganghwensis strain VG4 and its potential for the synthesis of antimicrobial metabolites
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Computational Bioscience Research Center (CBRC)
Applied Mathematics and Computational Science Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Online Publication Date2018-08-24
Print Publication Date2018-09
Permanent link to this recordhttp://hdl.handle.net/10754/628490
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AbstractWith antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new antimicrobials. In this report, we present the draft genome sequence of the Zooshikella ganghwensis strain VG4, isolated from Red Sea sediments, that produces metabolites with antimicrobial properties. A genomic analysis reveals that it carries at least five gene clusters that have the potential to direct biosynthesis of bioactive secondary metabolites such as polyketides and nonribosomal peptides. By using in-silico approaches, we predict the structure of these metabolites.
CitationRehman Z ur, Alam I, Kamau AA, Bajic VB, Leiknes T (2018) Genome sequence analysis of Zooshikella ganghwensis strain VG4 and its potential for the synthesis of antimicrobial metabolites. Biotechnology Reports 19: e00278. Available: http://dx.doi.org/10.1016/j.btre.2018.e00278.
SponsorsThe research reported in this publication was supported by funding from the King Abdullah University of Science and Technology (KAUST), KAUST Office of Sponsored Research (OSR) under awards number URF/1/2302 and No URF/1/1976-02, and KAUST Base Research Fund (BAS/1/1606-01-01) and (BAS/1/1061-01-01) to VBB and TL, respectively. We are thankful to the technical staff at the Bioscience core labs of KAUST for their assistance with genomic DNA isolation and sequencing.